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2-propenyl (Z)-N,4-dimethoxybenzimidate | 701975-73-7

中文名称
——
中文别名
——
英文名称
2-propenyl (Z)-N,4-dimethoxybenzimidate
英文别名
prop-2-enyl (1Z)-N,4-dimethoxybenzenecarboximidate
2-propenyl (Z)-N,4-dimethoxybenzimidate化学式
CAS
701975-73-7
化学式
C12H15NO3
mdl
——
分子量
221.256
InChiKey
ILICVIUSNOSLOQ-SEYXRHQNSA-N
BEILSTEIN
——
EINECS
——
  • 物化性质
  • 计算性质
  • ADMET
  • 安全信息
  • SDS
  • 制备方法与用途
  • 上下游信息
  • 反应信息
  • 文献信息
  • 表征谱图
  • 同类化合物
  • 相关功能分类
  • 相关结构分类

计算性质

  • 辛醇/水分配系数(LogP):
    3
  • 重原子数:
    16
  • 可旋转键数:
    6
  • 环数:
    1.0
  • sp3杂化的碳原子比例:
    0.25
  • 拓扑面积:
    40
  • 氢给体数:
    0
  • 氢受体数:
    4

反应信息

  • 作为反应物:
    参考文献:
    名称:
    Imino 1,2-Wittig rearrangement of hydroximates and its application to synthesis of cytoxazone
    摘要:
    The imino 1,2-Wittig rearrangement of hydroximates provides a novel method for the construction of 2-hydroxyoxime ethers. Upon treatment with LDA, Z-hydroximates smoothly underwent stereoselective rearrangement to give Z-2-hydroxyoxime ethers in good yield, which were converted into amino alcohols. On the other hand, the rearrangement of E-hydroximates gave a mixture of E- and Z-2-hydroxyoxime ethers. This method was successfully applied to a practical synthesis of cytoxazone. (C) 2004 Elsevier Ltd. All rights reserved.
    DOI:
    10.1016/j.tet.2004.02.048
  • 作为产物:
    描述:
    N-methoxy-4-methoxylbenzamide四溴化碳 、 sodium hydride 、 三苯基膦 作用下, 以 四氢呋喃乙腈 为溶剂, 反应 7.0h, 生成 2-propenyl (Z)-N,4-dimethoxybenzimidate
    参考文献:
    名称:
    Imino 1,2-Wittig rearrangement of hydroximates and its application to synthesis of cytoxazone
    摘要:
    The imino 1,2-Wittig rearrangement of hydroximates provides a novel method for the construction of 2-hydroxyoxime ethers. Upon treatment with LDA, Z-hydroximates smoothly underwent stereoselective rearrangement to give Z-2-hydroxyoxime ethers in good yield, which were converted into amino alcohols. On the other hand, the rearrangement of E-hydroximates gave a mixture of E- and Z-2-hydroxyoxime ethers. This method was successfully applied to a practical synthesis of cytoxazone. (C) 2004 Elsevier Ltd. All rights reserved.
    DOI:
    10.1016/j.tet.2004.02.048
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文献信息

  • Imino 1,2-Wittig rearrangement of hydroximates and its application to synthesis of cytoxazone
    作者:Okiko Miyata、Tomoko Koizumi、Hiroshi Asai、Ryuichi Iba、Takeaki Naito
    DOI:10.1016/j.tet.2004.02.048
    日期:2004.4
    The imino 1,2-Wittig rearrangement of hydroximates provides a novel method for the construction of 2-hydroxyoxime ethers. Upon treatment with LDA, Z-hydroximates smoothly underwent stereoselective rearrangement to give Z-2-hydroxyoxime ethers in good yield, which were converted into amino alcohols. On the other hand, the rearrangement of E-hydroximates gave a mixture of E- and Z-2-hydroxyoxime ethers. This method was successfully applied to a practical synthesis of cytoxazone. (C) 2004 Elsevier Ltd. All rights reserved.
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