(E)-1-(4-chloro-2-methylphenyl)-5-(4-hydroxy-3-methoxyphenyl)pent-4-ene-1,3-dione | 1001204-16-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (E)-1-(4-chloro-2-methylphenyl)-5-(4-hydroxy-3-methoxyphenyl)pent-4-ene-1,3-dione
• CAS: 1001204-16-5
• 化学式: C₁₉H₁₇ClO₄
• 分子量: 344.795
• InChiKey: DIEHQIRGVVCSAD-ZZXKWVIFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  24
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.16
• 拓扑面积：
  63.6
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• Chemical Compounds
  申请人：Rees David Daryl

  公开号：US20080045591A1

  公开（公告）日：2008-02-21

  Compounds of general formula I: wherein: R 1 and R 2 are, independently of each other, selected from hydrogen, optionally substituted C 1-10 alkyl, optionally substituted —CO—(C 1-10 alkyl), optionally substituted C 3-10 cycloalkyl, optionally substituted —CO—(C 3-10 cycloalkyl), optionally substituted C 2-10 alkenyl, optionally substituted —CO—(C 2-10 alkenyl), optionally substituted aryl, and optionally substituted —CO-aryl, or R 1 and R 2 together represent an optionally substituted saturated or unsaturated C 1-10 alkylidene group, or an optionally substituted saturated or unsaturated C 3-10 cycloalkylidene group, or R 1 and R 2 together with the carbon atom to which they are attached represent an optionally substituted saturated or unsaturated organic ring containing 3, 4, 5, 6, 7 or 8 ring carbon atoms and optionally 1, 2 or 3 ring heteroatoms selected from O, N and S; R 3 , which may be the same as, or different from, either of R 1 and R 2 , is selected from optionally substituted C 1-10 alkyl, optionally substituted C 3-10 cycloalkyl, optionally substituted C 2-10 alkenyl, and optionally substituted aryl; R 4 , R 5 and R 6 are, independently of each other, selected from hydrogen, optionally substituted C 1-10 alkyl, OH, optionally substituted C 1-10 alkoxy, halo, optionally substituted aryloxy, optionally substituted (C 1-10 alkyl)-S(O) n — where n=0, 1 or 2, optionally substituted aryl-S(O) n — where n=0, 1 or 2, or R 4 is hydrogen and R 5 and R 6 together represent an optionally substituted saturated or unsaturated organic chain containing 1, 2, 3, 4, 5, 6 or 7 chain carbon atoms and optionally 1, 2 or 3 chain heteroatoms selected from O, N and S, provided that the chain is at least 3 atoms long; with the proviso that, when R 1 ═R 2 =hydrogen, then any optionally substituted C 1-10 alkyl or optionally substituted C 2-10 alkenyl for R 3 must have a branch point at one or more of the α and β positions counted from the carbonyl group (or tautomeric form thereof) to which R 3 is attached; or a physiologically acceptable salt, complex or prodrug thereof; are disclosed per se and for use in the treatment or prophylaxis of hypersensitivity, smooth muscle disorders, spasmodic conditions, allergic conditions, inflammatory conditions and/or pain.

  通式I的化合物： 其中： R1和R2独立地选自氢，可选取代的C1-10烷基，可选取代的—CO—（C1-10烷基），可选取代的C3-10环烷基，可选取代的—CO—（C3-10环烷基），可选取代的C2-10烯基，可选取代的—CO—（C2-10烯基），可选取代的芳基和可选取代的—CO-芳基，或者R1和R2一起代表一个可选取代的饱和或不饱和的C1-10烷基亚基，或一个可选取代的饱和或不饱和的C3-10环烷基亚基，或者R1和R2与它们连接的碳原子一起代表一个可选取代的含有3、4、5、6、7或8个环碳原子和可选取代的1、2或3个从O、N和S中选取的环杂原子的饱和或不饱和的有机环； R3可以与R1和R2中的任何一个相同或不同，选自可选取代的C1-10烷基，可选取代的C3-10环烷基，可选取代的C2-10烯基和可选取代的芳基； R4、R5和R6独立地选自氢，可选取代的C1-10烷基，OH，可选取代的C1-10烷氧基，卤素，可选取代的芳氧基，可选取代的（C1-10烷基）-S（O）n-，其中n=0、1或2，可选取代的芳基-S（O）n-，其中n=0、1或2，或者R4为氢，R5和R6一起代表一个可选取代的含有1、2、3、4、5、6或7个链碳原子和可选取代的1、2或3个链杂原子的饱和或不饱和的有机链，前提是该链至少由3个原子组成； 但是，当R1=R2=氢时，R3必须选取一个可选取代的C1-10烷基或可选取代的C2-10烯基，其中至少有一个分支点位于从R3所连接的羰基（或其互变异构体）计算的α和β位置之一；或其生理上可接受的盐、络合物或前药，本发明公开了其本身和用于治疗或预防过敏、平滑肌障碍、痉挛性疾病、过敏性疾病、炎症性疾病和/或疼痛。
• US7589123B2
  申请人：——

  公开号：US7589123B2

  公开（公告）日：2009-09-15