1,2,3-Trimethyl-hexahydropyrimidin | 22385-47-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑烷类
• 英文名称: 1,2,3-Trimethyl-hexahydropyrimidin
• 英文别名: InChI=1/C7H16N2/c1-7-8(2)5-4-6-9(7)3/h7H,4-6H2,1-3H；1,2,3-trimethyl-1,3-diazinane
• CAS: 22385-47-3
• 化学式: C₇H₁₆N₂
• 分子量: 128.217
• InChiKey: GRHNKLNJAYKFIG-UHFFFAOYSA-N

物化性质

• 沸点：
  139.5±8.0 °C(Predicted)
• 密度：
  0.863±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  9
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  6.5
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• [EN] NOVEL TETRAZINE COMPOUNDS FOR IN VIVO IMAGING<br/>[FR] NOUVEAUX COMPOSÉS DE TÉTRAZINE POUR L'IMAGERIE IN VIVO
  申请人：UNIV COPENHAGEN

  公开号：WO2020108720A1

  公开（公告）日：2020-06-04

  The present invention relates to novel tetrazine compounds of formula I, wherein one of R1-R5 is 18F, for use in pretargeted in vivo imaging. The compounds are suitable for use in click chemistry, i.e. reactions that join a targeting molecule and a reporter molecule. The invention further relates to precursors to formula I, wherein one of R1-R5 is SnR3, B(OR)2, B(0H)2. Formula (I).

  本发明涉及一种新型四氮唑化合物，其化学式为I，其中R1-R5中的一个是18F，用于靶向体内成像。这些化合物适用于点击化学，即将靶向分子和报告分子结合的反应。该发明还涉及化合物I的前体，其中R1-R5中的一个是SnR3，B(OR)2，B(0H)2。化学式(I)。
• [EN] HETEROCYCLIC COMPOUNDS AND METHODS OF USE<br/>[FR] COMPOSÉS HÉTÉROCYCLIQUES ET PROCÉDÉS D'UTILISATION
  申请人：INTEGRAL BIOSCIENCES PVT LTD

  公开号：WO2020012357A1

  公开（公告）日：2020-01-16

  The present invention discloses compounds useful in treatment of conditions associated with excessive activity of transforming growth factor beta (TGF-β), particularly type 1 or activin-like kinase 5 (ALK 5). Specifically the present invention discloses compound of formula (I) which exhibit inhibitory activity against ALK 5. Method of treating conditions associated with excessive activity (ALK 5) with such compound is disclosed. Uses thereof, pharmaceutical composition, and kits are also disclosed.

  本发明揭示了在治疗与转化生长因子β（TGF-β）过度活性相关的疾病中有用的化合物，特别是针对类型1或类活化激酶5（ALK 5）。具体来说，本发明揭示了具有对ALK 5具有抑制活性的化合物的结构式（I）。还公开了使用这种化合物治疗与过度活性（ALK 5）相关的疾病的方法。此外，还公开了这些化合物的用途、制药组合物和试剂盒。
• ORGANIC ELECTRONIC MATERIAL, POLYMERIZATION INITIATOR AND THERMAL POLYMERIZATION INITIATOR, INK COMPOSITION, ORGANIC THIN FILM AND PRODUCTION METHOD FOR SAME, ORGANIC ELECTRONIC ELEMENT, ORGANIC ELECTROLUMINESCENT ELEMENT, LIGHTING DEVICE, DISPLAY ELEMENT, AND DISPLAY DEVICE
  申请人：Ishitsuka Kenichi

  公开号：US20130037753A1

  公开（公告）日：2013-02-14

  Disclosed is an organic electronic material comprising charge transporting compounds and ionic compounds having electron-accepting properties and high solubility in a solvent. The organic electronic material is characterized by comprising charge transporting compounds and ionic compounds, and in that at least one of the ionic compounds is any one kind of compounds represented by general formulas (1b)-(3b). (In the formulas Y 1 -Y 6 each independently represent a divalent linking group, R 1 -R 6 each independently represent an electron-attracting organic substituent (these structures can further have substituents and hetero-atoms, and R 1 , R 2 and R 3 , or, R 4 -R 6 can respectively combine and become a ring shape or a polymer shape) and L + represents a monovalent cation.)

  本文揭示了一种有机电子材料，包括具有电荷传输化合物和具有接受电子性质且在溶剂中具有高溶解度的离子化合物。该有机电子材料的特点在于包括电荷传输化合物和离子化合物，并且至少其中一个离子化合物是由通用式（1b）-（3b）表示的化合物中的任意一种。（在式中，Y1-Y6分别表示二价连接基团，R1-R6分别表示吸引电子的有机取代基（这些结构可以进一步具有取代基和杂原子，且R1、R2和R3，或者R4-R6可以分别结合形成环状或聚合物形状），L+表示一价阳离子。）
• Non-aqueous absorbent and use thereof
  申请人：Sumiya Takashi

  公开号：US20050136247A1

  公开（公告）日：2005-06-23

  A non-aqueous absorbent comprising a crosslinked polymer which contains a structural unit having a carboxyl group and/or a sulfonate group in an amount of 20 to 100% weight in its molecule and in which from 30 to 100% by mol of the protons in the carboxyl group and/or the sulfonate group have been substituted by onium cations; a non-aqueous gel made of this non-aqueous absorbent and an organic solvent; and a non-aqueous absorbent sheet and a non-aqueous absorbent agent containing the non-aqueous absorbent. Because of having excellent capabilities of absorbing and holding various organic solvents such as alcohols and gelating, these materials are usable for various purposes, for example, lithium batteries, alcohol-based bactericidal materials or alcohol-based bactericides, cold insulating materials or cold insulators, gel sheets for cooling, fuel compositions for solid fuels or solid fuels using the same, fragrance materials or fragrances, patch materials or patches, insecticidal compositions or insecticides, fuel stores for fuel batteries or fuel batteries using the same.

  一种非水吸收剂，包含交联聚合物，其分子中含有具有羧基和/或磺酸基的结构单元，其含量为20至100％重量，并且其中羧基和/或磺酸基中的30至100％摩尔的质子已被离子上离子替代物取代；由此制成的非水凝胶和有机溶剂；以及含有非水吸收剂的非水吸收剂片和非水吸收剂剂。由于具有吸收和保持各种有机溶剂（如醇类）的能力，以及凝胶化，这些材料可用于各种用途，例如锂电池，醇基杀菌材料或醇基杀菌剂，冷绝缘材料或冷绝缘材料，用于冷却的凝胶片，用于固体燃料的燃料组合物或使用相同的固体燃料，香料材料或香料，贴片材料或贴片，杀虫组合物或杀虫剂，燃料电池的燃料存储器或使用相同的燃料电池。
• Novel Fluorinated Alkyl Fluorophosphoric Acid Salts of Onium and Ttransition Metal Complex
  申请人：Kimura Hideki

  公开号：US20070225458A1

  公开（公告）日：2007-09-27

  To obtain a polymerization initiator (acid generating agent) having excellent power for initiation of cationic polymerization without containing arsenic or antimony. [Means for solution] Provided is a specific onium salt or transition metal complex salt of a fluorinated alkyl fluorophosphoric acid.

  获取一种聚合引发剂（酸发生剂），具有优异的阳离子聚合引发能力，不含砷或锑。[解决方案的手段] 提供了一种特定的氟化烷基氟磷酸的烷基铵盐或过渡金属配合物盐。

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