7'-amino-6'-benzoyl-2'-phenyl-1'H,2H-spiro[acenaphthylene-1,5'-pyrazolo[1,2-a][1,2,4]triazole]-1',2,3'(2'H)-trione | 1395095-22-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 7'-amino-6'-benzoyl-2'-phenyl-1'H,2H-spiro[acenaphthylene-1,5'-pyrazolo[1,2-a][1,2,4]triazole]-1',2,3'(2'H)-trione
• 英文别名: 7'-Amino-6'-benzoyl-2'-phenylspiro[acenaphthylene-2,5'-pyrazolo[1,2-a][1,2,4]triazole]-1,1',3'-trione
• CAS: 1395095-22-3
• 化学式: C₂₉H₁₈N₄O₄
• 分子量: 486.486
• InChiKey: WUQXPPBCSJKVIM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  37
• 可旋转键数：
  3
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.03
• 拓扑面积：
  104
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  4-苯基脲唑 、 苯甲酰乙腈 、 苊醌 在 三乙胺 作用下， 以 乙醇 为溶剂， 反应 0.58h， 以85%的产率得到7'-amino-6'-benzoyl-2'-phenyl-1'H,2H-spiro[acenaphthylene-1,5'-pyrazolo[1,2-a][1,2,4]triazole]-1',2,3'(2'H)-trione
  参考文献：
  名称：

  An efficient ultrasound-promoted one pot synthesis of spiroacenaphthylene pyrazolotriazole and pyrazolophthalazine derivatives

  摘要：

  A facile and efficient one pot three-component ultrasound-promoted synthesis of spiro pyrazolo compounds has been developed. Employing ethanol as a solvent, assumed to be relatively environmentally benign, and use of an inexpensive and readily available catalyst combined with the advantages of sono-chemistry, such as mild reaction conditions, excellent yield, and short reaction times highlight this synthetic route. The reactions were carried out under both conventional heating and ultrasound-assisted conditions and several reaction parameters are investigated and compared. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2012.07.049