diethyl N--L-glutamate | 115827-03-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: diethyl N--L-glutamate
• 英文别名: diethyl N-[p-(N-benzyl-N-methylamino)benzoyl]-L-glutamate；diethyl (2S)-2-[[4-[benzyl(methyl)amino]benzoyl]amino]pentanedioate
• CAS: 115827-03-7
• 化学式: C₂₄H₃₀N₂O₅
• 分子量: 426.513
• InChiKey: UORMPFVPODIRKK-NRFANRHFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.33
• 重原子数：
  31.0
• 可旋转键数：
  11.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  84.94
• 氢给体数：
  1.0
• 氢受体数：
  6.0

反应信息

• 作为反应物：
  描述：

  diethyl N--L-glutamate 在 palladium on activated charcoal 盐酸 、 氢气 作用下， 以 乙醇 为溶剂， 反应 3.0h， 以80%的产率得到对甲胺基苯甲酰谷氨酸二乙酯
  参考文献：
  名称：

  A pyrimidine-based "flexible" bisubstrate analog inhibitor of human thymidylate synthase

  摘要：

  The synthesis and characterization of two "flexible" bisubstrate analogues of the intermediate in the thymidylate synthase reaction are reported. Steric constraints are minimized and diasteromeric mixtures avoided by using a pyrimidine-based analogue as the folate portion of the inhibitor while retaining all known important binding sites. A preliminary assessment of certain conformational parameters by NMR is presented. The compounds are shown to be potent competitive inhibitors with respect to dUMP or 5,10-CH2-H4PteGlu but gave mixed kinetics with respect to 5,10-CH2-H4PteGlu5 for human thymidylate synthase.

  DOI：

  10.1021/jm00119a012
• 作为产物：
  描述：

  N-(4-氨基苯(甲)酰)-L-谷氨酸二乙酯 在 溴甲酚绿 、 sodium cyanoborohydride 、 溶剂黄146 作用下， 以 乙醇 、 乙腈 为溶剂， 反应 49.0h， 生成 diethyl N--L-glutamate
  参考文献：
  名称：

  A pyrimidine-based "flexible" bisubstrate analog inhibitor of human thymidylate synthase

  摘要：

  The synthesis and characterization of two "flexible" bisubstrate analogues of the intermediate in the thymidylate synthase reaction are reported. Steric constraints are minimized and diasteromeric mixtures avoided by using a pyrimidine-based analogue as the folate portion of the inhibitor while retaining all known important binding sites. A preliminary assessment of certain conformational parameters by NMR is presented. The compounds are shown to be potent competitive inhibitors with respect to dUMP or 5,10-CH2-H4PteGlu but gave mixed kinetics with respect to 5,10-CH2-H4PteGlu5 for human thymidylate synthase.

  DOI：

  10.1021/jm00119a012

文献信息

• YANG, IN-YOUNG;SLUSHER, R. MARK;BROOM, ARTHUR D.;UEDA, T.;CHENG, YUNG-CHI, J. MED. CHEM., 31,(1988) N 11, C. 2126-2132
  作者：YANG, IN-YOUNG、SLUSHER, R. MARK、BROOM, ARTHUR D.、UEDA, T.、CHENG, YUNG-CHI

  DOI：——

  日期：——