8-acetylsulfanyl-6-mercapto-octanoic acid | 43047-65-0

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 8-acetylsulfanyl-6-mercapto-octanoic acid
• 英文别名: 8-Acetylmercapto-6-mercapto-octansaeure；8-acetylmercapto-6-mercaptooctanoic acid；8-acetylsulfanyl-6-sulfanyloctanoic acid
• CAS: 43047-65-0
• 化学式: C₁₀H₁₈O₃S₂
• 分子量: 250.383
• InChiKey: KJIYGVNILNZIBG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  15
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  80.7
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 盐酸 、 丙酮 作用下， 生成 8-acetylsulfanyl-6-mercapto-octanoic acid
  参考文献：
  名称：

  Biosynthesis and Structure of Lipoic Acid Derivatives¹

  摘要：

  DOI：

  10.1021/ja01589a079

文献信息

• Photo-reaction of lipoic acid and related organic disulphides: reductive acylation with aldehydes
  作者：Makoto Takagi、Setsuo Goto、Tsutomu Matsuda

  DOI：10.1039/c39760000092

  日期：——

  Irradiation of organic disulphides in aldehyde solvents resulted in reductive fission of the S–S linkage giving the corresponding thiol and an equimolar amount of the thiol acylate for linear disulphides and mono S-acylated dithiols for cyclic disulphides.

  在醛溶剂中辐照有机二硫化物会导致S–S键的还原裂变，从而为线性二硫化物提供相应的硫醇和等摩尔量的硫醇酰化物，对于环状二硫化物则为单S-酰化二硫醇。
• Lipoic acid derivatives and their use in treatment of disease
  申请人：——

  公开号：US20020107234A1

  公开（公告）日：2002-08-08

  This invention relates to the identification of a novel class of therapeutic agents which selectively target and kill tumor cells and certain other types of diseased cells, and to compositions comprising lipoic acid derivatives which poison the pyruvate dehydrogenase complex specifically in such cells. This invention also provides for methods of using therapeutically effective amounts of the lipoic acid derivatives for the treatment of cancer and other diseases. The lipoic acid derivatives described herein have a wide range of preventive and therapeutic applications.

  本发明涉及一种新型治疗剂的鉴定，该治疗剂选择性地针对并杀死肿瘤细胞和某些其他类型的疾病细胞，并且涉及包含脂酰辅酶A衍生物的组合物，该衍生物特异性地破坏这些细胞中的丙酮酸脱氢酶复合物。本发明还提供了使用治疗有效量的脂酰辅酶A衍生物治疗癌症和其他疾病的方法。本发明中描述的脂酰辅酶A衍生物具有广泛的预防和治疗应用。
• Dibenzyl lipoic acid derivatives and their use in treatment of disease
  申请人：The Research Foundation Of The State University Of New York

  公开号：EP2145883A1

  公开（公告）日：2010-01-20

  The invention provides a method of inhibiting proliferation of diseased cells by contacting the diseased cells with an effective amount of a reagent that inhibits PDC specifically in said diseased cells.

  本发明提供了一种抑制病变细胞增殖的方法，方法是将病变细胞与有效量的试剂接触，该试剂可特异性地抑制病变细胞中的 PDC。
• Lipoic acid and derivatives thereof for the treatment of cystinuria
  申请人：Buck Institute for Research on Aging

  公开号：US10052305B2

  公开（公告）日：2018-08-21

  In various embodiments methods and composition are provided for the treatment and/or prophylaxis of cystinuria. In certain embodiments the methods involve administering to a mammal in need thereof (e.g., identified as at risk for, or having cystinuria) an effective amount of lipoic acid and/or one or more lipoic acid derivatives.

  在各种实施方案中，提供了治疗和/或预防胱氨酸尿症的方法和组合物。在某些实施方案中，这些方法涉及向有需要的哺乳动物（例如，确定为有胱氨酸尿症风险或患有胱氨酸尿症）施用有效量的硫辛酸和/或一种或多种硫辛酸衍生物。
• Okawara,M. et al., Israel Journal of Chemistry, 1978, vol. 17, p. 264 - 268
  作者：Okawara,M. et al.

  DOI：——

  日期：——