Boc-Lys(COCF3)-Lys(COCF3)-Gly-OCH2Ph | 142824-66-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Boc-Lys(COCF3)-Lys(COCF3)-Gly-OCH2Ph
• CAS: 142824-66-6
• 化学式: C₃₀H₄₁F₆N₅O₈
• 分子量: 713.675
• InChiKey: PZNDLLXFGISROW-SFTDATJTSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.92
• 重原子数：
  49.0
• 可旋转键数：
  18.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  181.03
• 氢给体数：
  5.0
• 氢受体数：
  8.0

反应信息

• 作为反应物：
  描述：

  Boc-Lys(COCF3)-Lys(COCF3)-Gly-OCH2Ph 在 palladium on activated charcoal 氢气 、 caesium carbonate 作用下， 以 甲醇 、 N,N-二甲基甲酰胺 为溶剂， 反应 120.0h， 生成 {[(8R,11R)-11-tert-Butoxycarbonylamino-10-oxo-3,16-bis-(2,2,2-trifluoro-acetyl)-3,9,16-triaza-bicyclo[16.2.2]docosa-1(21),18(22),19-triene-8-carbonyl]-amino}-acetic acid
  参考文献：
  名称：

  Synthesis of Doubly Cross-Linked Cyclic Hexapeptides

  摘要：

  Cyclic hexapeptides in which the adjacent N(epsilon)-nitrogens of cyclo-(Lys-Lys-Gly)2 are cross-linked by p-xylyl or (CH2)6 units have been prepared. The key steps in the syntheses of these novel types of peptide were the use of tosyl (or, less efficiently, trifluoroacetyl) as N(epsilon)-protection that allowed intramolecular cross-linking of the tripeptides Boc-Lys(R)-Lys(R)-Gly-OMe (R = Ts or CF3CO) using alpha,omega-dibromo-alkanes/ Cs2CO3, and the efficient cyclo-dimerisation of the pentafluoro-phenyl esters of the resultant cross-linked tripeptides.

  DOI：

  10.1016/s0040-4039(00)79854-6
• 作为产物：
  描述：

  丁氧羰基-羟基化赖氨酸(TFA) 、 在 1-羟基苯并三唑 、 N,N-二异丙基乙胺 、 N,N'-二环己基碳二亚胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成 Boc-Lys(COCF3)-Lys(COCF3)-Gly-OCH2Ph
  参考文献：
  名称：

  Synthesis of Doubly Cross-Linked Cyclic Hexapeptides

  摘要：

  Cyclic hexapeptides in which the adjacent N(epsilon)-nitrogens of cyclo-(Lys-Lys-Gly)2 are cross-linked by p-xylyl or (CH2)6 units have been prepared. The key steps in the syntheses of these novel types of peptide were the use of tosyl (or, less efficiently, trifluoroacetyl) as N(epsilon)-protection that allowed intramolecular cross-linking of the tripeptides Boc-Lys(R)-Lys(R)-Gly-OMe (R = Ts or CF3CO) using alpha,omega-dibromo-alkanes/ Cs2CO3, and the efficient cyclo-dimerisation of the pentafluoro-phenyl esters of the resultant cross-linked tripeptides.

  DOI：

  10.1016/s0040-4039(00)79854-6