2-[4-(2,5-difluoro-phenoxy)-2-oxo-2H-pyridin-1-yl]-4-methyl-pentanoic acid (1-methyl-1H-pyrazol-3-yl)-amide | 1262239-25-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-[4-(2,5-difluoro-phenoxy)-2-oxo-2H-pyridin-1-yl]-4-methyl-pentanoic acid (1-methyl-1H-pyrazol-3-yl)-amide
• 英文别名: 2-[4-(2,5-difluorophenoxy)-2-oxopyridin-1-yl]-4-methyl-N-(1-methylpyrazol-3-yl)pentanamide
• CAS: 1262239-25-7
• 化学式: C₂₁H₂₂F₂N₄O₃
• 分子量: 416.427
• InChiKey: AXSDMXASMQDFII-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  30
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  76.5
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• PYRIDONE GLUCOKINASE ACTIVATORS
  申请人：Haynes Nancy-Ellen

  公开号：US20110021570A1

  公开（公告）日：2011-01-27

  Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of metabolic diseases and disorders such as, for example, type II diabetes mellitus.

  本文提供了公式(I)的化合物，以及其药学上可接受的盐，其中取代基如规范中所披露。这些化合物及其含有它们的药物组合物对代谢性疾病和疾病的治疗有用，例如II型糖尿病。
• [EN] PYRIDONE GLUCOKINASE ACTIVATORS<br/>[FR] ACTIVATEURS DE LA GLUCOKINASE À BASE DE PYRIDINE
  申请人：HOFFMANN LA ROCHE

  公开号：WO2011009845A1

  公开（公告）日：2011-01-27

  Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of metabolic diseases and disorders such as, for example, type II diabetes mellitus.