2-amino-5-[5-(2,4-dimethoxy-pyrimidin-5-yl)-furan-2-ylmethylene]-3,5-dihydro-imidazol-4-one | 1263777-64-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-amino-5-[5-(2,4-dimethoxy-pyrimidin-5-yl)-furan-2-ylmethylene]-3,5-dihydro-imidazol-4-one
• 英文别名: (4E)-2-amino-4-[[5-(2,4-dimethoxypyrimidin-5-yl)furan-2-yl]methylidene]-1H-imidazol-5-one
• CAS: 1263777-64-5
• 化学式: C₁₄H₁₃N₅O₄
• 分子量: 315.288
• InChiKey: CEEBJLCKQZCYCQ-WEVVVXLNSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  125
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• Furan-imidazolone derivatives, for the treatment of cognitive, neurodegenerative or neuronal diseases or disorders
  申请人：NOSCIRA, S.A.

  公开号：EP2281824A1

  公开（公告）日：2011-02-09

  The present invention is related to a family of furan-imidazolone derivatives of formula (I), and to their use in the treatment of cognitive, neurodegenerative or neuronal diseases or disorders, such as Alzheimer's disease or Parkinson's Disease. The present invention also relates to pharmaceutical compositions comprising the same.

  本发明涉及一类含有呋喃-咪唑啉酮衍生物的公式(I)化合物家族，以及它们在治疗认知、神经退行性或神经性疾病或障碍，如阿尔茨海默病或帕金森病中的应用。本发明还涉及包含相同化合物的药物组合物。
• [EN] FURAN-IMIDAZOLONE DERIVATIVES, FOR THE TREATMENT OF COGNITIVE, NEURODEGENERATIVE OR NEURONAL DISEASES OR DISORDERS<br/>[FR] DÉRIVÉS DE FURANE-IMIDAZOLONE POUR LE TRAITEMENT DE MALADIES OU TROUBLES COGNITIFS, NEURODÉGÉNÉRATIFS OU NEURONAUX
  申请人：NOSCIRA SA

  公开号：WO2011015646A2

  公开（公告）日：2011-02-10

  The present invention is related to a family of furan-imidazolone derivatives of formula (I), and to their use in the treatment of cognitive, neurodegenerative or neuronal diseases or disorders, such as Alzheimer's disease or Parkinson's Disease. The present invention also relates to pharmaceutical compositions comprising the same.