8-bromo-2-(4-bromo-2,6-diisopropylphenyl)-5,12-bis(4-(2,4,4-trimethylpentan-2-yl)phenoxy)-1H-benzo[10,5]anthra[2,1,9-def]isoquinoline-1,3(2H)-dione | 1373140-25-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 菲及其衍生物
• 英文名称: 8-bromo-2-(4-bromo-2,6-diisopropylphenyl)-5,12-bis(4-(2,4,4-trimethylpentan-2-yl)phenoxy)-1H-benzo[10,5]anthra[2,1,9-def]isoquinoline-1,3(2H)-dione
• CAS: 1373140-25-0
• 化学式: C₆₂H₆₅Br₂NO₄
• 分子量: 1048.01
• InChiKey: ZRMDGRHFUSSBFL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  19.32
• 重原子数：
  69.0
• 可旋转键数：
  11.0
• 环数：
  9.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  55.84
• 氢给体数：
  0.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  8-bromo-2-(4-bromo-2,6-diisopropylphenyl)-5,12-bis(4-(2,4,4-trimethylpentan-2-yl)phenoxy)-1H-benzo[10,5]anthra[2,1,9-def]isoquinoline-1,3(2H)-dione 在 甲醇 、 bis-triphenylphosphine-palladium(II) chloride 、 copper(l) iodide 、 二异丙胺 、 sodium hydroxide 作用下， 以 四氢呋喃 、 甲苯 为溶剂， 反应 24.0h， 生成 8-ethynyl-2-(4-ethynyl-2,6-diisopropylphenyl)-5,12-bis(4-(2,4,4-trimethylpentan-2-yl)phenoxy)-1H-benzo[10,5]anthra[2,1,9-def]isoquinoline-1,3(2H)-dione
  参考文献：
  名称：

  Strain Release in Organic Photonic Nanoparticles for Protease Sensing

  摘要：

  Proteases are overexpressed in most cancers and proteolytic activity has been shown to be a viable marker for cancer imaging in vivo. Herein, we describe the synthesis of luminescence-quenched shell cross-linked nanoparticles as photonic nanoprobes for protease sensing. Protease sensing scheme is based on a "turn-on" mechanism where the protease cleaves peptide cross-linkers of the fluorescence-quenched shell cross-linked NP (OFF state) leading to a highly emissive non-cross linked NP (ON state). The cross-linked particles can be strained by exposure to a good solvent and proteolysis allows for particle expansion (swelling) and a recovery of the luminescence.

  DOI：

  10.1021/ja301259v
• 作为产物：
  描述：

  1,6,9-tribromo-N-(4-bromo-2,6-diisopropylphenyl)-3,4-perylenedicarboximide 、 对特辛基苯酚 在 potassium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 2.5h， 以40%的产率得到8-bromo-2-(4-bromo-2,6-diisopropylphenyl)-5,12-bis(4-(2,4,4-trimethylpentan-2-yl)phenoxy)-1H-benzo[10,5]anthra[2,1,9-def]isoquinoline-1,3(2H)-dione
  参考文献：
  名称：

  Strain Release in Organic Photonic Nanoparticles for Protease Sensing

  摘要：

  Proteases are overexpressed in most cancers and proteolytic activity has been shown to be a viable marker for cancer imaging in vivo. Herein, we describe the synthesis of luminescence-quenched shell cross-linked nanoparticles as photonic nanoprobes for protease sensing. Protease sensing scheme is based on a "turn-on" mechanism where the protease cleaves peptide cross-linkers of the fluorescence-quenched shell cross-linked NP (OFF state) leading to a highly emissive non-cross linked NP (ON state). The cross-linked particles can be strained by exposure to a good solvent and proteolysis allows for particle expansion (swelling) and a recovery of the luminescence.

  DOI：

  10.1021/ja301259v