2-Methyl-decahydro-[2]naphthol | 92057-76-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-Methyl-decahydro-[2]naphthol
• 英文别名: 2-Methyl-decalol-(2)；2-methyl-3,4,4a,5,6,7,8,8a-octahydro-1H-naphthalen-2-ol
• CAS: 92057-76-6
• 化学式: C₁₁H₂₀O
• 分子量: 168.279
• InChiKey: TWDPXQUZDUKBLQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2-Methyl-decahydro-[2]naphthol 在 硫酸 作用下， 生成 2-Methyl-dekalin-carbonsaeure-(2)-methylester
  参考文献：
  名称：

  Koch,H.; Haaf,W., Chemische Berichte, 1961, vol. 94, p. 1252 - 1259

  摘要：

  DOI：
• 作为产物：
  描述：

  (+/-)-trans,trans-decahydro-2-naphthol 在 chromium(VI) oxide 、 硫酸 、 苯 作用下， 生成 2-Methyl-decahydro-[2]naphthol
  参考文献：
  名称：

  聚萜烯和聚萜烯LIX。合成倍半萜烯的化学合成

  摘要：

  DOI：

  10.1002/hlca.19310140523

文献信息

• 240. Fused carbon rings. Part XIII. Synthesis of derivatives of decalin containing an angular methyl group
  作者：R. P. Linstead、A. F. Millidge、A. L. Walpole

  DOI：10.1039/jr9370001140

  日期：——
• METHOD TO TREAT SICKLE CELL DISEASE
  申请人：Linden M. Joel

  公开号：US20080009460A1

  公开（公告）日：2008-01-10

  The present invention provides a therapeutic method for treating an inflammatory response caused by a sickle cell crisis, comprising administration of an effective amount amount of an A 2A adenosine receptor agonist. Optionally, the method includes administration of a type IV PDE inhibitor (e.g., rolipram).
• METHOD TO TREAT GASTRIC LESIONS
  申请人：Linden M. Joel

  公开号：US20080027022A1

  公开（公告）日：2008-01-31

  The present invention provides a therapeutic method for treating gastric lesions, including administration to a patient in need thereof of an effective amount of an A 2A adenosine receptor agonist. The A 2A adenosine receptor agonist can be a compound of formula (I) as disclosed herein. The invention further provides a therapeutic method for treating the patient with an A 2A adenosine receptor agonist, optionally, in combination with a Type IV phosphodiesterase (PDE) inhibitor. In one embodiment, the gastric lesions are caused by, or aggravated by, the use of NSAIDS such as, for example, aspirin.
• USE OF ADENOSINE A2A MODULATORS TO TREAT SPINAL CORD INJURY
  申请人：Li Jason Yuesheng

  公开号：US20080064653A1

  公开（公告）日：2008-03-13

  The present invention is a method for treatment or prevention of injury to nerve cells. The method can use at least one A 2A receptor modulator to prevent injury to or enhance the healing of the injured cells.
• AGONISTS OF A2A ADENOSINE RECEPTORS FOR TREATING RECURRENT TUMOR GROWTH IN THE LIVER FOLLOWING RESECTION
  申请人：Kranenburg Onno

  公开号：US20080262001A1

  公开（公告）日：2008-10-23

  The present invention relates to a method for treating recurrent tumor metastases following liver resection that includes administration of an effective amount of an agonist of A 2A adenosine receptors (ARs).