2,3-dibromo-3-phenyl-1-thiophen-2-yl-propan-1-one | 27241-60-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2,3-dibromo-3-phenyl-1-thiophen-2-yl-propan-1-one
• 英文别名: 2,3-dibromo-3-phenyl-1-[2]thienyl-propan-1-one；2,3-Dibrom-3-phenyl-1-[2]thienyl-propan-1-on；2,3-Dibrom-1--3-phenylpropanon-(1)；1-(2-Thienyl)-2,3-dibrom-3-phenyl-1-propanon；2,3-Dibromo-3-phenyl-1-thiophen-2-ylpropan-1-one；2,3-dibromo-3-phenyl-1-thiophen-2-ylpropan-1-one
• CAS: 27241-60-7
• 化学式: C₁₃H₁₀Br₂OS
• 分子量: 374.096
• InChiKey: XDRVYKNHQFYDSX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  45.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2,3-dibromo-3-phenyl-1-thiophen-2-yl-propan-1-one 、 氨基硫脲 在 三乙胺 作用下， 以 乙醇 为溶剂， 反应 24.0h， 以35%的产率得到4,5-dihydro-5-hydroxy-3-phenyl-5-(thiophen-2-yl)pyrazole-1-carbothioamide
  参考文献：
  名称：

  Synthesis and Characterization of a New Series of Hydroxy Pyrazolines

  摘要：

  3-Phenyl-1-(thiophen-2-yl)prop-2-en-1-one obtained by Claisen-Schmidt condensation of 2-acetyl thiophene with benzaldehyde was converted into 2,3-dibromo-3-phenyl-1-(thiophen-2-yl)propan-1-one, which on treatment with various thiosemicarbazides in the presence of triethylamine in absolute ethanol, yielded the corresponding hydroxy pyrazolines 3a-h. All the compounds were characterized by IR, (1)H NMR, and (13)C NMR spectra.

  DOI：

  10.1080/00397910802241407
• 作为产物：
  描述：

  3-苯基-1-(2-噻吩)-2-丙烯-1-酮 在 溴 作用下， 以 氯仿 为溶剂， 反应 24.0h， 以96%的产率得到2,3-dibromo-3-phenyl-1-thiophen-2-yl-propan-1-one
  参考文献：
  名称：

  Synthesis and Characterization of a New Series of Hydroxy Pyrazolines

  摘要：

  3-Phenyl-1-(thiophen-2-yl)prop-2-en-1-one obtained by Claisen-Schmidt condensation of 2-acetyl thiophene with benzaldehyde was converted into 2,3-dibromo-3-phenyl-1-(thiophen-2-yl)propan-1-one, which on treatment with various thiosemicarbazides in the presence of triethylamine in absolute ethanol, yielded the corresponding hydroxy pyrazolines 3a-h. All the compounds were characterized by IR, (1)H NMR, and (13)C NMR spectra.

  DOI：

  10.1080/00397910802241407

文献信息

• Brunswig, Chemische Berichte, 1886, vol. 19, p. 2893
  作者：Brunswig

  DOI：——

  日期：——
• Synthesis and Characterization of a New Series of Hydroxy Pyrazolines
  作者：Humaira Parveen、Prince Firdoos Iqbal、Amir Azam

  DOI：10.1080/00397910802241407

  日期：2008.10.28

  3-Phenyl-1-(thiophen-2-yl)prop-2-en-1-one obtained by Claisen-Schmidt condensation of 2-acetyl thiophene with benzaldehyde was converted into 2,3-dibromo-3-phenyl-1-(thiophen-2-yl)propan-1-one, which on treatment with various thiosemicarbazides in the presence of triethylamine in absolute ethanol, yielded the corresponding hydroxy pyrazolines 3a-h. All the compounds were characterized by IR, (1)H NMR, and (13)C NMR spectra.