(R)-3-(tert-butyldiphenylsilyloxy)-5-[(R,E)-1-hydroxy-3-(tributylstannyl)allyl]-5-methylfuran-2(5H)-one | 1057675-81-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 内酯类
• 英文名称: (R)-3-(tert-butyldiphenylsilyloxy)-5-[(R,E)-1-hydroxy-3-(tributylstannyl)allyl]-5-methylfuran-2(5H)-one
• CAS: 1057675-81-6
• 化学式: C₃₆H₅₄O₄SiSn
• 分子量: 697.618
• InChiKey: NQYDBNGVJQXAOF-CQMLMSOMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.07
• 重原子数：
  42.0
• 可旋转键数：
  16.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  55.76
• 氢给体数：
  1.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  (R)-3-(tert-butyldiphenylsilyloxy)-5-[(R,E)-1-hydroxy-3-(tributylstannyl)allyl]-5-methylfuran-2(5H)-one 、 (1E,5E,7E)-(3R,9S)-1-Iodo-3,5,9-trimethyl-undeca-1,5,7-triene 在 双(乙腈)氯化钯(II) 作用下， 以 various solvent(s) 为溶剂， 反应 0.03h， 以32%的产率得到
  参考文献：
  名称：

  The total synthesis and biological evaluation of nafuredin-γ and its analogues

  摘要：

  Nafuredin (1) is converted to nafuredin-gamma (2) under mild basic conditions and both compounds exhibit the same inhibitory activity and selectivity against NADH-fumarate reductase (complex 1). The total synthesis of 2 was achieved by a convergent approach using Stille coupling. The structural elements required for inhibitory activity against NADH-fumarate reductase (complex I) were then investigated by evaluation of nafuredin-gamma (2) and its structural analogues. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2008.06.066