(R)-1-(2-(dimethylamino)-1-(4-benzyloxyphenyl)ethyl)cyclohexanol | 1049700-96-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: (R)-1-(2-(dimethylamino)-1-(4-benzyloxyphenyl)ethyl)cyclohexanol
• 英文别名: 1-[(1R)-2-(dimethylamino)-1-(4-phenylmethoxyphenyl)ethyl]cyclohexan-1-ol
• CAS: 1049700-96-0
• 化学式: C₂₃H₃₁NO₂
• 分子量: 353.505
• InChiKey: FSSWQHLSQWTHIB-QFIPXVFZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  26
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.48
• 拓扑面积：
  32.7
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (R)-1-(2-(dimethylamino)-1-(4-benzyloxyphenyl)ethyl)cyclohexanol 在 palladium 10% on activated carbon 盐酸 、 氢气 作用下， 以 乙醇 、 水 为溶剂， 生成 (-)-O-desmethylvenlafaxine hydrochloride
  参考文献：
  名称：

  WO2008/103461

  摘要：

  公开号：
• 作为产物：
  描述：

  1-[1-(4-苄氧基苯基)-2-(二甲基氨基)乙基]环己醇 在 sodium hydroxide 作用下， 以 甲基叔丁基醚 、 水 、 丙酮 为溶剂， 反应 4.91h， 生成 (R)-1-(2-(dimethylamino)-1-(4-benzyloxyphenyl)ethyl)cyclohexanol
  参考文献：
  名称：

  WO2008/103461

  摘要：

  公开号：

文献信息

• Solid forms comprising (-)-O-desmethylvenlafaxine and uses thereof
  申请人：Sizensky Michael

  公开号：US20090005457A1

  公开（公告）日：2009-01-01

  Solid forms comprising a compound useful in the treatment, prevention and management of various conditions and diseases are provided herein. In particular, the invention provides solid forms comprising (−)—O-desmethylvenlafaxine, including salts thereof, having utility for the treatment, prevention and management of conditions and disorders including, but not limited to, affective disorders such as depression, bipolar and manic disorders, attention deficit disorder, attention deficit disorder with hyperactivity, Parkinson's disease, epilepsy, cerebral function disorders, obesity and weight gain, incontinence, dementia and related disorders.

  本文提供了包含一种化合物的固体形式，该化合物对于治疗、预防和管理各种疾病和病症具有有用性。具体而言，本发明提供包含（-）-O-去甲基文拉法辛及其盐的固体形式，可用于治疗、预防和管理情感障碍如抑郁症、双相和躁狂障碍、注意力缺陷障碍、注意力缺陷障碍伴有多动症、帕金森病、癫痫、脑功能障碍、肥胖和体重增加、失禁、痴呆及相关疾病等病症。
• Solid form comprising (-) o-desmethylvenlafaxine and uses thereof
  申请人：Sepracor Inc.

  公开号：EP2500337A2

  公开（公告）日：2012-09-19

  Solid forms comprising a compound useful in the treatment, prevention and management of various conditions and diseases are provided herein. In particular, the invention provides solid forms comprising (-)-O-desmethylvenlafaxine, including salts thereof, having utility for the treatment, prevention and management of conditions and disorders including, but not limited to, affective disorders such as depression, bipolar and manic disorders, attention deficit disorder, attention deficit disorder with hyperactivity, Parkinson's disease, epilepsy, cerebral function disorders, obesity and weight gain, incontinence, dementia and related disorders.

  本发明提供了包含可用于治疗、预防和控制各种病症和疾病的化合物的固体形式。特别是，本发明提供了包含(-)-O-去甲文拉法辛（包括其盐）的固体形式，可用于治疗、预防和控制各种病症和疾病，包括但不限于情感障碍，如抑郁症、双相情感障碍和躁狂症、注意力缺陷障碍、注意力缺陷障碍伴多动、帕金森病、癫痫、脑功能障碍、肥胖和体重增加、大小便失禁、痴呆及相关疾病。
• SOLID FORMS COMPRISING (-) O-DESMETHYLVENLAFAXINE AND USES THEREOF
  申请人：Sepracor Inc.

  公开号：EP2114863A2

  公开（公告）日：2009-11-11
• SOLID FORMS COMPRISING (-)-O-DESMETHYLVENLAFAXINE AND USES THEREOF
  申请人：Sepracor Inc.

  公开号：EP2114863B1

  公开（公告）日：2016-10-05
• Solid Forms Comprising(-)-O-Desmethylvenlafaxine And Uses Thereof
  申请人：Sunovion Pharmaceuticals Inc.

  公开号：US20160355457A1

  公开（公告）日：2016-12-08

  Solid forms comprising a compound useful in the treatment, prevention and management of various conditions and diseases are provided herein. In particular, the invention provides solid forms comprising (−)-O-desmethylvenlafaxine, including salts thereof, having utility for the treatment, prevention and management of conditions and disorders including, but not limited to, affective disorders such as depression, bipolar and manic disorders, attention deficit disorder, attention deficit disorder with hyperactivity, Parkinson's disease, epilepsy, cerebral function disorders, obesity and weight gain, incontinence, dementia and related disorders.