4,5-dihydroxy-tetrahydro-pyran-2-carboxylic acid | 133844-86-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡喃
• 英文名称: 4,5-dihydroxy-tetrahydro-pyran-2-carboxylic acid
• 英文别名: 4,5-Dihydroxy-tetrahydro-pyran-2-carbonsaeure；4,5-Dihydroxyoxane-2-carboxylic acid
• CAS: 133844-86-7
• 化学式: C₆H₁₀O₅
• 分子量: 162.142
• InChiKey: YRPRHLNMFWDGSL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.4
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  87
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  4,5-dihydroxy-tetrahydro-pyran-2-carboxylic acid 生成 alkaline earth salt of/the/ methylsulfuric acid
  参考文献：
  名称：

  Borsche, Chemische Berichte, 1916, vol. 49, p. 2544

  摘要：

  DOI：
• 作为产物：
  描述：

  5-羟基-4-氧-4H-2-羧酸 在 乙醇 、 氢气 、 钯 作用下， 生成 4,5-dihydroxy-tetrahydro-pyran-2-carboxylic acid
  参考文献：
  名称：

  Borsche, Chemische Berichte, 1916, vol. 49, p. 2544

  摘要：

  DOI：

文献信息

• PROCESS FOR PREPARING HEPARINOIDS AND INTERMEDIATES USEFUL IN THE SYNTHESIS THEREOF
  申请人：KOVI Ravishanker

  公开号：US20130005954A1

  公开（公告）日：2013-01-03

  Processes are disclosed for the synthesis of the Factor Xa anticoagulant fondaparinux and related compounds. Protected pentasaccharide intermediates and efficient and scalable processes for the industrial scale production of fondaparinux sodium by conversion of the protected pentasaccharide intermediates via a sequence of deprotection and sulfonation reactions are provided.

  公开了合成因子Xa抗凝剂磺达肝癸钠及其相关化合物的方法。提供了受保护的五糖中间体以及通过一系列去保护和磺化反应将受保护五糖中间体转化为磺达肝癸钠的工业规模生产的高效和可扩展过程。
• Low molecular weight polysaccharides having antithrombotic activity
  申请人：Oreste Anna Pasqua

  公开号：US20070155694A1

  公开（公告）日：2007-07-05

  Novel depolymerized-LMWepiK5-N,O-sulfates obtainable starting from a LMW-epiK5-N-sulfate prepared by nitrous depolymerization of an epiK5-N-sulfate or by C5-epimerization of a LMW-K5-N-sulfate obtained by nitrous depolymerization of a K5-N-sulfate. A process consists of submitting the starting depolymerized-LMW-epiK5-N-sulfate to four steps: a O-oversulfation, a partila O-desulfation, a 6-O-sulfation and a N-sulfation. The new depolymerized-LMWepiK5-N,O-sulfates present a di- or trisulfated 2,5-anhydromannitol unit at the reducing end of the majority of its chains, have a content of iduronic acid of 40-60%, a sulfation degree of from 2.3 to 2.9 and a mean molecular weight of from about 1,500 to about 12,000. They exhibit a good antithrombotic activity with a low pro-hemorrhagic risk.

  由通过硝基降解epiK5-N-硫酸盐或通过硝基降解K5-N-硫酸盐获得的LMW-epiK5-N-硫酸盐制备的Novel depolymerized-LMWepiK5-N,O-硫酸盐，或通过C5-表异构化得到的LMW-K5-N-硫酸盐。该过程包括将起始的去聚合-LMW-epiK5-N-硫酸盐提交给四个步骤：O-过度硫酸化，部分O-脱硫酸化，6-O-硫酸化和N-硫酸化。新的去聚合-LMWepiK5-N,O-硫酸盐在其大部分链的还原端具有二硫酸化或三硫酸化的2,5-脱水甘露糖单元，具有40-60％的异硫酸酸含量，2.3至2.9的硫酸化程度和约1,500至约12,000的平均分子量。它们表现出良好的抗血栓形成活性，低的促出血风险。
• ANTICOAGULANT REVERSAL AGENTS
  申请人：PEROSPHERE INC.

  公开号：US20170056396A1

  公开（公告）日：2017-03-02

  Novel anticoagulant reversal compounds are disclosed, as well as methods of making the compounds, pharmaceutical compositions including the compounds, methods of using the compounds to reverse the anticoagulant effects of coagulation inhibitors, and diagnostic assays comprising the compounds.

  揭示了新型抗凝血逆转化合物，以及制备该化合物的方法，包括该化合物的制药组合物，使用该化合物逆转凝血抑制剂的抗凝血效果的方法，以及包含该化合物的诊断测定方法。
• PROCESS FOR THE PREPARATION OF HIGHLY O-SULFATED EPIMERIZED DERIVATIVES OF K5 POLYSACCHARIDE AND INTERMEDIATES THEREIN
  申请人：ORESTE Pasqua Anna

  公开号：US20120253029A1

  公开（公告）日：2012-10-04

  A new method is described for the oversulfation of epiK5-N-sulfate to obtain an epiK5-amine-O-oversulfate with very high sulfation degree which, by subsequent N-sulfation, provides new epiK5-N,O-oversulfate-derivatives with a sulfation degree of at least 4, basically free of activity on the coagulation parameters and useful in the cosmetic or pharmaceutical field. Also described are new low molecular weight epiK5-N-sulfates useful as intermediates in the preparation of the corresponding LMW-epiK5-N,O-oversulfate-derivatives.

  一种新方法被描述用于过度硫酸化epiK5-N-硫酸盐以获得具有非常高的硫酸化程度的epiK5-胺基-O-过度硫酸盐，通过随后的N-硫酸化，提供至少4个硫酸化程度的新的epiK5-N，O-过度硫酸盐衍生物，在凝血参数上基本上没有活性，并且在化妆品或制药领域中有用。还描述了新的低分子量epiK5-N-硫酸盐，可用作制备相应的LMW-epiK5-N，O-过度硫酸盐衍生物的中间体。
• Advanced drug development and manufacturing
  申请人：Los Alamos National Security, LLC

  公开号：EP2511844A2

  公开（公告）日：2012-10-17

  There is described an apparatus for measuring protein characteristics comprising an X-ray fluorescence (XRF) spectrometer comprising a source of polychromatic X-rays, an X-ray detector, a protein, a molecule that has been exposed to and at least weakly binds to the protein, a plurality of X-ray fluorescence signal data obtained by irradiating chemical elements in the protein and molecule with the polychromatic X-rays and a security system for maintaining records for the data from the plurality of X-ray fluorescence signal measurements. There is also described an x-ray microscope for measuring a sample.

  描述了一种测量蛋白质特性的仪器，该仪器包括一个 X 射线荧光 (XRF) 光谱仪，其中包括一个多色 X 射线源、一个 X 射线探测器、一个蛋白质、一个已暴露于该蛋白质并至少与该蛋白质弱结合的分子、通过用多色 X 射线照射蛋白质和分子中的化学元素而获得的多个 X 射线荧光信号数据，以及一个用于维护多个 X 射线荧光信号测量数据记录的安全系统。此外，还介绍了一种用于测量样品的 X 射线显微镜。