D-sorbose 1,6-bisphosphate | 136598-68-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: D-sorbose 1,6-bisphosphate
• 英文别名: [(2R,3S,4R)-2,3,4-trihydroxy-5-oxo-6-phosphonooxyhexyl] dihydrogen phosphate
• CAS: 136598-68-0
• 化学式: C₆H₁₄O₁₂P₂
• 分子量: 340.117
• InChiKey: XPYBSIWDXQFNMH-PYWDMBMJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -5.4
• 重原子数：
  20
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  211
• 氢给体数：
  7
• 氢受体数：
  12

反应信息

• 作为产物：
  描述：

  1-羟基-3-(磷酰氧基)-2-丙酮 、 D-甘油醛3-磷酸酯 在 rabbit muscle aldolase 、 sodium hydroxide 作用下， 以 水 为溶剂， 反应 0.17h， 生成 D-sorbose 1,6-bisphosphate
  参考文献：
  名称：

  .alpha.-Amino aldehyde equivalents as substrates for rabbit muscle aldolase: synthesis of 1,4-dideoxy-D-arabinitol and 2(R),5(R)-bis(hydroxymethyl)-3(R),4(R)-dihydroxypyrrolidine

  摘要：

  This work examined the application of rabbit muscle aldolase (RAMA) to stereospecific carbon-carbon bond formation in the preparation of carbohydrates containing amino groups. Several alpha-amino aldehyde equivalents were evaluated as substrates for RAMA and for their synthetic utility in transformations following the aldol reaction. This methodology is illustrated by the syntheses of the pyrrolidine alkaloids 1,4-dideoxy-D-arabinitol and 2(R),5(R)-bis(hydroxymethyl)-3(R), 4(R)-dihydroxypyrrolidine. The kinetic resolution of racemic aldehydes by RAMA and mild methods for transforming the amino equivalents into the desired amines are discussed briefly.

  DOI：

  10.1021/jo00012a015