tert-butyl 1-(2-bromoethyl)-4-hydroxy-2,5-dimethoxy-4-(3-methylbut-3-en-1-ynyl)-cyclohexa-2,5-dienecarboxylate | 1071817-79-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: tert-butyl 1-(2-bromoethyl)-4-hydroxy-2,5-dimethoxy-4-(3-methylbut-3-en-1-ynyl)-cyclohexa-2,5-dienecarboxylate
• CAS: 1071817-79-2
• 化学式: C₁₅H₂₁BrO₅
• 分子量: 361.233
• InChiKey: DYTLITXNYRUZJY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.74
• 重原子数：
  21.0
• 可旋转键数：
  5.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  61.83
• 氢给体数：
  0.0
• 氢受体数：
  5.0

反应信息

• 作为反应物：
  描述：

  tert-butyl 1-(2-bromoethyl)-4-hydroxy-2,5-dimethoxy-4-(3-methylbut-3-en-1-ynyl)-cyclohexa-2,5-dienecarboxylate 、 2-甲基-1-丁烯-3-炔 在 正丁基锂 、 水 、 氯化铵 作用下， 以 乙醚 、 正己烷 为溶剂， 反应 4.0h， 生成 tert-butyl 1-(2-bromoethyl)-4-hydroxy-2,5-dimethoxy-4-(3-methylbut-3-en-1-ynyl)cyclohexa-2,5-dienecarboxylate
  参考文献：
  名称：

  A Route to 1,4-Disubstituted Aromatics and Its Application to the Synthesis of the Antibiotic Culpin

  摘要：

  A method is described for converting tert-butyl benzoates or tert-butyl 1-naphthoates into derivatives having an alkyl or substituted alkyl group in a 1,4-relationship to an alkyl, aryl, alkenyl, or alkynyl group. Key steps in the sequence are (i) addition of an organometallic species to a cross-conjugated cyclohexadienone obtained by Birch alkylation of a tert-butyl benzoate or a tert-butyl 1-naphthoate, followed by allylic oxidation, and (ii) treatment with BiCl3 center dot H2O, which results in removal of the tertbutyl group and spontaneous decarboxylative aromatization. The method was applied to the synthesis of the antimicrobial fungal metabolite culpin.

  DOI：

  10.1021/jo8015192
• 作为产物：
  描述：

  tert-butyl (2-bromoethyl)-2,5-dimethoxy-1-cyclohexa-2,5-dienecarboxylate 在 叔丁基过氧化氢 、 重铬酸吡啶 、 Celite 作用下， 以 癸烷 、 苯 为溶剂， 反应 2.5h， 以1.12 g的产率得到tert-butyl 1-(2-bromoethyl)-4-hydroxy-2,5-dimethoxy-4-(3-methylbut-3-en-1-ynyl)-cyclohexa-2,5-dienecarboxylate
  参考文献：
  名称：

  A Route to 1,4-Disubstituted Aromatics and Its Application to the Synthesis of the Antibiotic Culpin

  摘要：

  A method is described for converting tert-butyl benzoates or tert-butyl 1-naphthoates into derivatives having an alkyl or substituted alkyl group in a 1,4-relationship to an alkyl, aryl, alkenyl, or alkynyl group. Key steps in the sequence are (i) addition of an organometallic species to a cross-conjugated cyclohexadienone obtained by Birch alkylation of a tert-butyl benzoate or a tert-butyl 1-naphthoate, followed by allylic oxidation, and (ii) treatment with BiCl3 center dot H2O, which results in removal of the tertbutyl group and spontaneous decarboxylative aromatization. The method was applied to the synthesis of the antimicrobial fungal metabolite culpin.

  DOI：

  10.1021/jo8015192