2-(2-(2-(2-(adamantyl-1-oxy)ethoxy)ethoxy)ethoxy)ethanethiol | 1313583-22-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-(2-(2-(2-(adamantyl-1-oxy)ethoxy)ethoxy)ethoxy)ethanethiol
• CAS: 1313583-22-0
• 化学式: C₁₈H₃₂O₄S
• 分子量: 344.516
• InChiKey: MWMNXYWYKGNQEV-UHFFFAOYSA-N

反应信息

• 作为产物：
  描述：

  2-bromoethyl triethylene glycol adamantyl ether 在 sodium thiosulfate 、 硫酸 、 水 作用下， 以 乙醇 、 水 为溶剂， 反应 25.0h， 生成 2-(2-(2-(2-(adamantyl-1-oxy)ethoxy)ethoxy)ethoxy)ethanethiol
  参考文献：
  名称：

  Probing Multivalent Interactions in a Synthetic Host–Guest Complex by Dynamic Force Spectroscopy

  摘要：

  Multivalency is present in many biological and synthetic systems. Successful application of multivalency depends on a correct understanding of the thermodynamics and kinetics of this phenomenon. In this Article, we address the stability and strength of multivalent bonds with force spectroscopy techniques employing a synthetic adamantane/beta-cyclodextrin model system. Comparing the experimental findings to theoretical predictions for the rupture force and the kinetic off-rate, we find that when the valency of the complex is increased from mono- to di- to trivalent, there is a transition from quasi-equilibrium, with a constant rupture force of 99 pN, to a kinetically dependent state, with loading-rate-dependent rupture forces from 140 to 184 pN (divalent) and 175 to 210 pN (trivalent). Additional binding geometries, parallel monovalent ruptures, single-bound divalent ruptures, and single- and double-bound trivalent ruptures are identified. The experimental kinetic off-rates of the multivalent complexes show that the stability of the complexes is significantly enhanced with the number of bonds, in agreement with the predictions of a noncooperative multivalent model.

  DOI：

  10.1021/ja2016125