1-(2-{[6-bromo-2-(tert-butyldimethylsilanyloxymethyl)-3-methoxymethoxyphenyl]-hydroxy-methyl}-3-methoxymethoxy-phenyl)-6-(tert-butyldimethylsilanyloxy)-hexan-1-ol | 565176-51-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 1-(2-{[6-bromo-2-(tert-butyldimethylsilanyloxymethyl)-3-methoxymethoxyphenyl]-hydroxy-methyl}-3-methoxymethoxy-phenyl)-6-(tert-butyldimethylsilanyloxy)-hexan-1-ol
• CAS: 565176-51-4
• 化学式: C₃₆H₆₁BrO₈Si₂
• 分子量: 757.951
• InChiKey: JBKHEYMWJCVFMN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9.63
• 重原子数：
  47.0
• 可旋转键数：
  19.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  95.84
• 氢给体数：
  2.0
• 氢受体数：
  8.0

反应信息

• 作为反应物：
  描述：

  1-(2-{[6-bromo-2-(tert-butyldimethylsilanyloxymethyl)-3-methoxymethoxyphenyl]-hydroxy-methyl}-3-methoxymethoxy-phenyl)-6-(tert-butyldimethylsilanyloxy)-hexan-1-ol 在 2-碘酰基苯甲酸 作用下， 以 二甲基亚砜 为溶剂， 反应 6.0h， 以385 mg的产率得到1-{2-[6-Bromo-2-(tert-butyl-dimethyl-silanyloxymethyl)-3-methoxymethoxy-benzoyl]-3-methoxymethoxy-phenyl}-6-(tert-butyl-dimethyl-silanyloxy)-hexan-1-one
  参考文献：
  名称：

  Studies towards the total synthesis of mumbaistatin: synthesis of highly substituted benzophenone and anthraquinone building blocks

  摘要：

  Model compounds and building blocks for a planned total synthesis of the highly potent glucose-6-phosphate (G6P) translocase inhibitor mumbaistatin (1) and structural analogs were elaborated: compound 1 represents a lead structure in the development of potential new antidiabetic drugs. With the model substrate 20 it was demonstrated that highly functionalized, tetra-ortho-substituted benzophenones can be prepared by nucleophilic addition of an aryllithium-building block to a benzaldehyde followed by oxidation. For compound 37, a potential precursor of the anthraquinone part of mumbaistatin, various approaches via aryne/phthalide annulations were developed and evaluated. The required functionalized arenes were prepared exploiting, among others, regioselective bromination and ortho-lithiation reactions. Coupling reactions of the anthracene-carbaldehyde 44 derived from 37 with various metalated arenes proved to be unexpectedly difficult and failed so far. (C) 2003 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(03)00427-7
• 作为产物：
  描述：

  4-bromo-2,3-bis(hydroxymethyl)phenol 在 正丁基锂 、 草酸氯化物 、 sodium hydride 、 二甲基亚砜 、 三乙胺 作用下， 以 四氢呋喃 、 正己烷 、 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 1.67h， 生成 1-(2-{[6-bromo-2-(tert-butyldimethylsilanyloxymethyl)-3-methoxymethoxyphenyl]-hydroxy-methyl}-3-methoxymethoxy-phenyl)-6-(tert-butyldimethylsilanyloxy)-hexan-1-ol
  参考文献：
  名称：

  Studies towards the total synthesis of mumbaistatin: synthesis of highly substituted benzophenone and anthraquinone building blocks

  摘要：

  Model compounds and building blocks for a planned total synthesis of the highly potent glucose-6-phosphate (G6P) translocase inhibitor mumbaistatin (1) and structural analogs were elaborated: compound 1 represents a lead structure in the development of potential new antidiabetic drugs. With the model substrate 20 it was demonstrated that highly functionalized, tetra-ortho-substituted benzophenones can be prepared by nucleophilic addition of an aryllithium-building block to a benzaldehyde followed by oxidation. For compound 37, a potential precursor of the anthraquinone part of mumbaistatin, various approaches via aryne/phthalide annulations were developed and evaluated. The required functionalized arenes were prepared exploiting, among others, regioselective bromination and ortho-lithiation reactions. Coupling reactions of the anthracene-carbaldehyde 44 derived from 37 with various metalated arenes proved to be unexpectedly difficult and failed so far. (C) 2003 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(03)00427-7