propyl 4-(4-hydroxyphenyl)benzoate | 131802-88-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: propyl 4-(4-hydroxyphenyl)benzoate
• 英文别名: Propyl 4'-hydroxy[1,1'-biphenyl]-4-carboxylate
• CAS: 131802-88-5
• 化学式: C₁₆H₁₆O₃
• 分子量: 256.301
• InChiKey: KANPNOFIOQEUMD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  19
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  propyl 4-(4-hydroxyphenyl)benzoate 在 sodium hydride 、 氨基磺酰氯 作用下， 以 N,N-二甲基甲酰胺 、 甲苯 为溶剂， 反应 10.5h， 生成 4-Propyl 4'-[(aminosulfonyl)oxy][1,1'-biphenyl]-4-carboxylate
  参考文献：
  名称：

  Design, synthesis and biochemical evaluation of aC ring mimics as novel inhibitors of the enzyme estrone sulfatase (ES)

  摘要：

  We report the initial results of our study into a series of simple 4'-O-sulfamoyl-4-biphenyl based compounds as novel inhibitors of the enzyme estrone sulfatase (ES). The results of the study show that these compounds are potent inhibitors, possessing greater inhibitory activity than COUMATE, but weaker inhibitory activity than EMATE or the tricyclic derivative of COUMATE. namely 667-COUMATE. Furthermore, the compounds are observed to be irreversible inhibitors. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(02)00170-1
• 作为产物：
  描述：

  4-溴-4′-甲氧基联苯 在 溴乙烷 、 氢溴酸 、 氢气 、 magnesium 作用下， 以 乙醚 、 溶剂黄146 、 甲苯 为溶剂， 反应 2.0h， 生成 propyl 4-(4-hydroxyphenyl)benzoate
  参考文献：
  名称：

  Surendranath, V.; Fishel, D. L.; Vries, A de, Molecular Crystals and Liquid Crystals (1969-1991), 1985, vol. 131, p. 1 - 8

  摘要：

  DOI：

文献信息

• Method of producing thermotropic liquid crystalline polyester
  申请人：MITSUBISHI CHEMICAL CORPORATION

  公开号：EP0520428A2

  公开（公告）日：1992-12-30

  A thermotropic liquid crystalline polyester is produced by carrying out polycondensation of ester monomer [I-2], an aromatic dicarboxylic acid [II] and an aromatic carboxylic acid [III-2]. The amounts of the compounds [I-2] and [II] are substantially equivalent and the amount of the compound [III-2] is not more than 20 times that of [I-2] by mole. A thermotropic liquid crystalline polyester having good heat resistance, fluidity and uniformity can be produced.

  通过酯单体[I-2]、芳香族二羧酸[II]和芳香族羧酸[III-2]的缩聚反应，生产出一种热致性液晶聚酯。化合物[I-2]和[II]的量基本相等，化合物[III-2]的量不超过[I-2]的 20 倍（以摩尔计）。这样就可以生产出具有良好耐热性、流动性和均匀性的热致性液晶聚酯。
• Precise Synthesis and Surface Wettability of a Polymer with Liquid Crystalline Side Chains
  作者：Tomoyasu Hirai、Shota Osumi、Hiroki Ogawa、Teruaki Hayakawa、Atsushi Takahara、Keiji Tanaka

  DOI：10.1021/ma5010265

  日期：2014.8.12

  Well-defined poly(methacrylate)s with liquid crystal side chains, designated as PPHM, were synthesized by a living anionic polymerization method. Introducing a short-length alkyl chain at the end of the side chain, the solubility of the polymer was improved, resulting in higher molecular weight polymers. While the highest weight-average molecular weight (M-w) of PPHM was 68k, it exceeded 100k for a slight-polydisperse PPHM. Wide-angle X-ray diffraction (WAXD) revealed that PPHM formed a smectic A phase with 2.7 nm layer spacing and that the layer structure is present even in the glassy state at room temperature. Molecular aggregation states of PPHM in surface regions of films were characterized by sum-frequency generation, grazing-incidence WAXD, and contact angle measurements. The results show that the PPHM with a larger M-w formed a layer structure parallel to the film plane. Although low M-w PPHM also maintained a layer structure, the structure became more random within internal regions. The surface reorganization of PPHM with larger M-w was suppressed in comparison with smaller ones.
• US5298593A
  申请人：——

  公开号：US5298593A

  公开（公告）日：1994-03-29
• Design, synthesis and biochemical evaluation of aC ring mimics as novel inhibitors of the enzyme estrone sulfatase (ES)
  作者：Sabbir Ahmed、Karen James、Caroline P. Owen、Chirag K. Patel

  DOI：10.1016/s0960-894x(02)00170-1

  日期：2002.5

  We report the initial results of our study into a series of simple 4'-O-sulfamoyl-4-biphenyl based compounds as novel inhibitors of the enzyme estrone sulfatase (ES). The results of the study show that these compounds are potent inhibitors, possessing greater inhibitory activity than COUMATE, but weaker inhibitory activity than EMATE or the tricyclic derivative of COUMATE. namely 667-COUMATE. Furthermore, the compounds are observed to be irreversible inhibitors. (C) 2002 Elsevier Science Ltd. All rights reserved.
• Surendranath, V.; Fishel, D. L.; Vries, A de, Molecular Crystals and Liquid Crystals (1969-1991), 1985, vol. 131, p. 1 - 8
  作者：Surendranath, V.、Fishel, D. L.、Vries, A de、Mahmood, R.、Johnson, D. L.

  DOI：——

  日期：——