(-)-(1R,3aR,7aS)-methyl 2-oxo-2,3,3a,4,7,7a-hexahydro-1H-indene-1-carboxylate | 1353665-28-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (-)-(1R,3aR,7aS)-methyl 2-oxo-2,3,3a,4,7,7a-hexahydro-1H-indene-1-carboxylate
• 英文别名: methyl (1R,3aR,7aS)-2-oxo-1,3,3a,4,7,7a-hexahydroindene-1-carboxylate
• CAS: 1353665-28-7
• 化学式: C₁₁H₁₄O₃
• 分子量: 194.23
• InChiKey: GBRNLRRSNLLKNQ-KHQFGBGNSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.64
• 拓扑面积：
  43.4
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• [EN] [6+5] FUSED BICYCLES AS A THROMBIN ANTAGONIST, PROCESS FOR PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE BICYCLES<br/>[FR] BICYCLES FUSIONNÉS [6+5] EN TANT QU'ANTAGONISTES DE LA THROMBINE, PROCÉDÉ DE PRÉPARATION DE CEUX-CI ET COMPOSITIONS PHARMACEUTIQUES CONTENANT LES BICYCLES
  申请人：KOREA RES INST CHEM TECH

  公开号：WO2011162562A2

  公开（公告）日：2011-12-29

  The present invention relates to the new [6+5] fused bicycle derivatives, pharmaceutically acceptable salts or isomers thereof, processes for preparing the same, and pharmaceutical compositions comprising the same. The [6+5] fused bicycle derivatives can antagonize the thrombin receptor and thus may be effectively used for the treatment and prevention of thrombus, platelet aggregation, atherosclerosis, restenosis, blood coagulation, hypertension, arrhythmia, angina pectoris, heart failure, inflammation and cancer when used alone or with other cardiovascular agents.