2,2,5,5-tetramethyl-1,6-diphenylhexane | 133055-13-7

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• 英文名称: 2,2,5,5-tetramethyl-1,6-diphenylhexane
• 英文别名: 1,6-Diphenyl-2,2,5,5-tetramethylhexane；(2,2,5,5-Tetramethyl-6-phenylhexyl)benzene
• CAS: 133055-13-7
• 化学式: C₂₂H₃₀
• 分子量: 294.48
• InChiKey: BEKVKSNTHBCGMA-UHFFFAOYSA-N

物化性质

• 沸点：
  405.3±15.0 °C(Predicted)
• 密度：
  0.934±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  7.6
• 重原子数：
  22
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为产物：
  描述：

  1-碘-2,2-二甲基-3-苯基丙烷 、 氢化铝锂 生成 2,2,5,5-tetramethyl-1,6-diphenylhexane
  参考文献：
  名称：

  YUAN, KAIXU;SCOTT, WILLIAM J., J. ORG. CHEM., 55,(1990) N5, C. 6188-6194

  摘要：

  DOI：

文献信息

• Nickel-catalyzed cross-coupling of unactivated neopentyl iodides with Grignard reagents
  作者：Kaixu Yuan、William J. Scott

  DOI：10.1016/0040-4039(91)80851-v

  日期：1991.1

  Primary neopentyl iodides react with aryl Grignard reagents in the presence of 10 mol% (dppf)NiCl2 to give the cross-coupled product.

  伯新戊基碘化物与芳基格氏试剂在10摩尔％（dppf）NiCl 2的存在下反应，生成交联产物。
• Penenory, Alicia B.; Rossi, Roberto A., Gazzetta Chimica Italiana, 1995, vol. 125, # 12, p. 605 - 610
  作者：Penenory, Alicia B.、Rossi, Roberto A.

  DOI：——

  日期：——
• On the mechanism of the reduction of primary halides with Grignard reagents in the presence of (dppf)PdCl2 or (dppf)Pd(0)
  作者：Kaixu Yuan、William J. Scott

  DOI：10.1021/jo00312a028

  日期：1990.12
• Nickel-mediated cross-coupling of unactivated neopentyl iodides with organozincs
  作者：Kwangyong Park、Kaixu Yuan、William J. Scott

  DOI：10.1021/jo00070a022

  日期：1993.8

  (dppf)NiCl2 catalyzes the cross-coupling of unactivated primary neopentyl iodides with diorganozinc reagents. The zinc nucleophiles are formed by the treatment of ZnCl2.dioxane with 2 mol equiv of a Grignard reagent in an ethereal solvent. The cross-coupling works optimally for diorganozincs formed from aryl chlorides or CH3MgCl. Use of aryl bromides can cause reduction and/or reductive dimerization of the electrophile. The analogous reaction with (CH3)2CuMgCl in either the presence or the absence of Group 10 metal catalysts failed to afford reasonable yields of cross-coupled products. The diorganozinc methodology overcomes many of the side reactions observed with the (dppf)-NiCl2-mediated cross-coupling of Grignard reagents.
• Reaction of 1-Substituted 2,2-Dimethyl-3-phenylpropane with <i>t</i>-BuOK in DMSO. An Unexpected Formation of a Cyclopropane Ring
  作者：Juan E. Argüello、Alicia B. Peñéñory、Roberto A. Rossi

  DOI：10.1021/jo9905165

  日期：1999.8.1