1-(6'-Deoxy-β-D-allofuranosyl)-cytosin | 1246254-90-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-(6'-Deoxy-β-D-allofuranosyl)-cytosin
• 英文别名: 4-amino-1-(β-D-6-deoxy-allofuranosyl)-1H-pyrimidin-2-one；5'-methylcytidine；4-amino-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(1-hydroxyethyl)oxolan-2-yl]pyrimidin-2-one
• CAS: 1246254-90-9
• 化学式: C₁₀H₁₅N₃O₅
• 分子量: 257.246
• InChiKey: KPPPLADORXGUFI-KCRXGDJASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.3
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  129
• 氢给体数：
  4
• 氢受体数：
  5

文献信息

• Antisense modulation of cellular inhibitor of apoptosis-1 expression
  申请人：——

  公开号：US20040009599A1

  公开（公告）日：2004-01-15

  Antisense compounds, compositions and methods are provided for modulating the expression of Cellular Inhibitor of Apoptosis-1. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding Cellular Inhibitor of Apoptosis-1. Methods of using these compounds for induction of cellular apoptosis are provided.

  提供了用于调节细胞凋亡抑制蛋白-1（Cellular Inhibitor of Apoptosis-1）表达的反义物质、组合物和方法。这些组合物包括特别针对编码细胞凋亡抑制蛋白-1的核酸的反义物质，特别是反义寡核苷酸。提供了利用这些化合物诱导细胞凋亡的方法。
• METHODS FOR THE TREATMENT OF HEPATITIS B AND HEPATITIS D VIRUS INFECTIONS
  申请人：REPLICOR INC.

  公开号：US20160008393A1

  公开（公告）日：2016-01-14

  It is disclosed a method for treating hepatitis B virus infection or hepatitis B virus/hepatits delta virus co-infection, the method comprising administering to a subject in need of such treatment a first pharmaceutically acceptable agent that comprises at least one phosphorothioated nucleic acid polymer and a second pharmaceutically acceptable agent that comprises at least one nucleoside/nucleotide analog HBV polymerase inhibitor.

  揭示了一种治疗乙型肝炎病毒感染或乙型肝炎病毒/丁型肝炎病毒共感染的方法，该方法包括向需要此类治疗的受试者施用至少包含一种磷硫酸酯核酸聚合物的第一种药用可接受剂和至少包含一种核苷/核苷酸类似物HBV聚合酶抑制剂的第二种药用可接受剂。
• SUBSTITUTED NUCLEOTIDE ANALOGS
  申请人：Beigelman Leonid

  公开号：US20120070411A1

  公开（公告）日：2012-03-22

  Disclosed herein are phosphoroamidate nucleotide analogs, methods of synthesizing phosphoroamidate nucleotide analogs and methods of treating diseases and/or conditions such as viral infections, cancer, and/or parasitic diseases with the phosphoroamidate nucleotide analogs.

  本文揭示了磷酰胺核苷类似物、合成磷酰胺核苷类似物的方法以及使用磷酰胺核苷类似物治疗病毒感染、癌症和/或寄生虫病等疾病和/或病况的方法。
• Oligonucleotide compositions and methods for the modulation of the expression of B7 protein
  申请人：——

  公开号：US20040235164A1

  公开（公告）日：2004-11-25

  Compositions and methods for the treatment of asthma with oligonucleotides which specifically hybridize with nucleic acids encoding B7 proteins.

  使用与编码B7蛋白质的核酸特异性杂交的寡核苷酸的组合物和方法，用于治疗哮喘。
• OLIGONUCLEOTIDE COMPOSITIONS AND METHODS FOR THE MODULATION OF THE EXPRESSION OF B7 PROTEIN
  申请人：Vickers Timothy

  公开号：US20080027019A1

  公开（公告）日：2008-01-31

  Compositions and methods for the treatment of asthma with oligonucleotides which specifically hybridize with nucleic acids encoding B7 proteins.

  使用特定杂交寡核苷酸处理哮喘的组合物和方法，这些寡核苷酸与编码B7蛋白质的核酸特异性杂交。