2-trans-Tetradec-1'-enyloxy-aethanol | 24435-65-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-trans-Tetradec-1'-enyloxy-aethanol
• 英文别名: 2-tetradec-1-en-t-yloxy-ethanol；2-[(E)-tetradec-1-enoxy]ethanol
• CAS: 24435-65-2
• 化学式: C₁₆H₃₂O₂
• 分子量: 256.429
• InChiKey: MIWCTHKOYOPQEC-FYWRMAATSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.2
• 重原子数：
  18
• 可旋转键数：
  14
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• METHOD FOR LOWERING CHOLESTEROL
  申请人：GOODENOWE Dayan Burke

  公开号：US20130046016A1

  公开（公告）日：2013-02-21

  The present invention relates to a method of lowering cholesterol in a patient in need thereof by administering to said patient a therapeutic effective amount of a compound selected from the group of Dihydroxyacetone phosphate (DHAP); 1-acyl-DHAP; 1-alkyl-DHAP; 1-alkyl-glyceraldehyde-3-phosphate (G3P); 1-alkyl, 2-acyl-G3P; 1-alkyl, 2-acyl-glycerol; 1-alkyl,2-acyl-glycerylphosphatidylethanolamine (GPE), 1-alkyl, diacyl glycerol (sn-1=16:0, sn-2=docosohexaenoic acid (DHA); sn-3=DHA) (sn-1 position has an alkyl ether bond, sn-2 and sn-3 positions have acyl bonds); 1-alkyl diacyl glycerol (sn-1=16:0, sn-2=18:1, sn-3=18:1) (sn-1 position has an alkyl ether bond, sn-2 and sn-3 positions have acyl bonds); triacyl glycerol (sn-1=16:0, sn-2=DHA, sn-3=DHA) (all three positions have acyl bonds); and triacyl glycerol (sn-1=16:0, sn-2=18:1, sn-3=18:1) (all three positions have acyl bonds) and pharmaceutically acceptable salts thereof.

  本发明涉及一种通过向需要降低胆固醇的患者施用从Dihydroxyacetone phosphate（DHAP）；1-acyl-DHAP；1-alkyl-DHAP；1-alkyl-glyceraldehyde-3-phosphate（G3P）；1-alkyl，2-acyl-G3P；1-alkyl，2-acyl-glycerol；1-alkyl，2-acyl-glycerylphosphatidylethanolamine（GPE）；1-alkyl，二酰基甘油酯（sn-1=16：0，sn-2=二十二碳六烯酸（DHA）；sn-3=DHA）（sn-1位具有烷基醚键，sn-2和sn-3位具有酰键）；1-烷基二酰基甘油酯（sn-1=16：0，sn-2=18：1，sn-3=18：1）（sn-1位具有烷基醚键，sn-2和sn-3位具有酰键）；三酰基甘油酯（sn-1=16：0，sn-2=DHA，sn-3=DHA）（所有三个位置均具有酰键）；以及三酰基甘油酯（sn-1=16：0，sn-2=18：1，sn-3=18：1）（所有三个位置均具有酰键）和其药学上可接受的盐的治疗有效量的化合物降低患者胆固醇的方法。
• EP2851369A2
  申请人：——

  公开号：EP2851369A2

  公开（公告）日：2015-03-25
• METHODS FOR THE DIAGNOSIS OF DEMENTIA AND OTHER NEUROLOGICAL DISORDERS
  申请人：Cook Lisa

  公开号：US20100003761A1

  公开（公告）日：2010-01-07

  The present invention is directed to a method for differentially diagnosing dementia or the risk of dementia in a patient. The method comprises obtaining a sample from the patient; analyzing the sample to obtain quantifying data for one or more than one metabolite marker; comparing the quantifying data for the one or more than one metabolite marker to corresponding data obtained from one or more than one reference sample; and using the comparison to differentially diagnose dementia or the risk of dementia. The method may also assis in assessing dementia or the risk of dementia in a patient. The present invention is also directed to metabolite markers and compounds useful in the present method.
• US8304246B2
  申请人：——

  公开号：US8304246B2

  公开（公告）日：2012-11-06