(2-(2-(2,2-dimethyl-1,3-dioxolan-4-yl)ethyl)phenyl)dimethylsilane | 1438825-14-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (2-(2-(2,2-dimethyl-1,3-dioxolan-4-yl)ethyl)phenyl)dimethylsilane
• CAS: 1438825-14-9
• 化学式: C₁₅H₂₄O₂Si
• 分子量: 264.44
• InChiKey: RVDIVAGXQCDEHY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.46
• 重原子数：
  18.0
• 可旋转键数：
  4.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  18.46
• 氢给体数：
  0.0
• 氢受体数：
  2.0

反应信息

• 作为反应物：
  描述：

  (2-(2-(2,2-dimethyl-1,3-dioxolan-4-yl)ethyl)phenyl)dimethylsilane 、 联硼酸频那醇酯 在 (1,5-cyclooctadiene)(methoxy)iridium(I) dimer 、 3,4,7,8-四甲基-1,10-菲罗啉 作用下， 以 四氢呋喃 为溶剂， 反应 36.0h， 以63%的产率得到(2-(2-(2,2-dimethyl-1,3-dioxolan-4-yl)-1-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)ethyl)phenyl)dimethylsilane
  参考文献：
  名称：

  Iridium-Catalyzed Borylation of Secondary Benzylic C–H Bonds Directed by a Hydrosilane

  摘要：

  Most functionalizations of C-H bonds by main-group reagents occur at aryl or methyl groups. We describe a highly regioselective borylation of secondary benzylic C-H bonds catalyzed by an iridium precursor and 3,4,7,8-tetramethyl-1,10-phenanthroline as the ligand. The reaction is directed to the benzylic position by a hydrosilyl substituent. This hydrosilyl directing group is readily deprotected or transformed to other functional groups after the borylation reaction, providing access to a diverse set of secondary benzylboronate esters by C-H borylation chemistry.

  DOI：

  10.1021/ja403462b
• 作为产物：
  描述：

  4-(2-溴苯基)-1-丁烯 在 sodium periodate 、 正丁基锂 、 对甲苯磺酸一水合物 、 溶剂黄146 、 lithium bromide 作用下， 以 四氢呋喃 、 正己烷 为溶剂， 反应 84.5h， 生成 (2-(2-(2,2-dimethyl-1,3-dioxolan-4-yl)ethyl)phenyl)dimethylsilane
  参考文献：
  名称：

  Iridium-Catalyzed Borylation of Secondary Benzylic C–H Bonds Directed by a Hydrosilane

  摘要：

  Most functionalizations of C-H bonds by main-group reagents occur at aryl or methyl groups. We describe a highly regioselective borylation of secondary benzylic C-H bonds catalyzed by an iridium precursor and 3,4,7,8-tetramethyl-1,10-phenanthroline as the ligand. The reaction is directed to the benzylic position by a hydrosilyl substituent. This hydrosilyl directing group is readily deprotected or transformed to other functional groups after the borylation reaction, providing access to a diverse set of secondary benzylboronate esters by C-H borylation chemistry.

  DOI：

  10.1021/ja403462b