{7-[3,4-diacetoxy-6-acetoxymethyl-5-(3,4,5-triacetoxy-6-acetoxymethyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-2-yloxy]-2-oxo-2H-chromen-4-yl}-acetic acid methyl ester | 929549-04-2

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 香豆素及其衍生物
• 英文名称: {7-[3,4-diacetoxy-6-acetoxymethyl-5-(3,4,5-triacetoxy-6-acetoxymethyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-2-yloxy]-2-oxo-2H-chromen-4-yl}-acetic acid methyl ester
• CAS: 929549-04-2
• 化学式: C₃₈H₄₄O₂₂
• 分子量: 852.754
• InChiKey: LNNHCQPWISNLHI-AWSCQIDJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.51
• 重原子数：
  60.0
• 可旋转键数：
  15.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  277.53
• 氢给体数：
  0.0
• 氢受体数：
  22.0

反应信息

• 作为反应物：
  描述：

  {7-[3,4-diacetoxy-6-acetoxymethyl-5-(3,4,5-triacetoxy-6-acetoxymethyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-2-yloxy]-2-oxo-2H-chromen-4-yl}-acetic acid methyl ester 在 甲醇 、 lithium hydroxide 、 sodium methylate 作用下， 以 四氢呋喃 、 水 为溶剂， 反应 5.0h， 生成 2-[7-[(2S,3R,4R,5S,6R)-3,4-dihydroxy-6-(hydroxymethyl)-5-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]oxy-2-oxochromen-4-yl]acetic acid
  参考文献：
  名称：

  Profiling of Glycosidase Activities Using Coumarin-Conjugated Glycoside Cocktails

  摘要：

  Glycosidases are a large subgroup of carbohydrate-processing enzymes that hydrolytically cleave the glycosidic bond. Glycans formed by the action of glycosidases are involved in various biological processes. Genetic abnormalities in glycosidases are associated with inherited diseases. Thus, characterization of the catalytic activities of glycosidases is of great importance. Herein, we describe a simple and rapid approach for determining glycosidase activity profiles using coumarin-conjugated glycoside cocktails.

  DOI：

  10.1021/ol062889f
• 作为产物：
  描述：

  7-hydroxycoumarin-4-acetic acid methyl ester sodium salt 、 乙酰溴代纤维二糖 在 四丁基硫酸氢铵 、 sodium carbonate 作用下， 以 氯仿 为溶剂， 反应 3.0h， 以64%的产率得到{7-[3,4-diacetoxy-6-acetoxymethyl-5-(3,4,5-triacetoxy-6-acetoxymethyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-2-yloxy]-2-oxo-2H-chromen-4-yl}-acetic acid methyl ester
  参考文献：
  名称：

  Profiling of Glycosidase Activities Using Coumarin-Conjugated Glycoside Cocktails

  摘要：

  Glycosidases are a large subgroup of carbohydrate-processing enzymes that hydrolytically cleave the glycosidic bond. Glycans formed by the action of glycosidases are involved in various biological processes. Genetic abnormalities in glycosidases are associated with inherited diseases. Thus, characterization of the catalytic activities of glycosidases is of great importance. Herein, we describe a simple and rapid approach for determining glycosidase activity profiles using coumarin-conjugated glycoside cocktails.

  DOI：

  10.1021/ol062889f