H-Ala-Arg-Arg-Cys(Acm)-Tyr-Asn-Asp-Pro-Lys-Cys(Acm)-Cys(SPyr)-Asp-Phe-OH | 1191395-99-9

• 分子结构分类: 有机化合物 - 有机聚合物 - 多肽
• 英文名称: H-Ala-Arg-Arg-Cys(Acm)-Tyr-Asn-Asp-Pro-Lys-Cys(Acm)-Cys(SPyr)-Asp-Phe-OH
• CAS: 1191395-99-9
• 化学式: C₇₆H₁₁₂N₂₄O₂₂S₄
• 分子量: 1842.14
• InChiKey: CTFVBLNPMFQECD-CIWLUXAUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -6.1
• 重原子数：
  126.0
• 可旋转键数：
  58.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.51
• 拓扑面积：
  762.56
• 氢给体数：
  26.0
• 氢受体数：
  28.0

反应信息

• 作为产物：
  描述：

  2,2'-二硫二吡啶 、 以 乙醇 为溶剂， 反应 1.0h， 以78%的产率得到H-Ala-Arg-Arg-Cys(Acm)-Tyr-Asn-Asp-Pro-Lys-Cys(Acm)-Cys(SPyr)-Asp-Phe-OH
  参考文献：
  名称：

  Synthesis and properties of a new conformational antigen which models an extracellular region of β1-adrenoreceptor

  摘要：

  Two fragments corresponding to the 125-133 and 206-218 sequences of a molecule of the beta 1-adrenoreceptor (autoantibodies to this protein are often found in patients with dilated cardiomyopathy) were synthesized by the solid phase method with the use of Fmoc technology. Two new conformational antigens were prepared by directed (regioselective) and undirected (spontaneous) formation of intramolecular and intermolecular disulfide bridges between the corresponding cysteine residues of the synthesized peptides. One of these antigens consisted of a mixture of disulfide isomers, and another antigen was an isomer with a natural arrangement of S-S bridges. Immunosorbents were obtained by immobilization of the synthesizes antigens on the bromocyanogen-activated sepharose and applied to the removal of autoantibodies in a beta 1-adrenoreceptor from the blood plasma of patients. We demonstrated that the sorbents on the basis of the conformational antigens were more effective in comparison with those containing linear peptide precursors.

  DOI：

  10.1134/s1068162009030029