4-(1-hydroxybutyl)cyclohexanone | 1352934-74-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4-(1-hydroxybutyl)cyclohexanone
• 英文别名: 4-(1-hydroxybutyl)cyclohexan-1-one
• CAS: 1352934-74-7
• 化学式: C₁₀H₁₈O₂
• 分子量: 170.252
• InChiKey: PUZFNEJGDSFIGS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• [EN] CYCLOHEXYL-AZETIDINYL ANTAGONISTS OF CCR2<br/>[FR] ANTAGONISTES DU CCR2 À BASE DE CYCLOHEXYL-AZÉTIDINYLE
  申请人：JANSSEN PHARMACEUTICA NV

  公开号：WO2011159854A1

  公开（公告）日：2011-12-22

  The present invention comprises compounds of Formula (I). Wherein: R1, R2, R4, J, Q, and A are as defined in the specification. The invention also comprises a method of preventing, treating or ameliorating a syndrome, disorder or disease, wherein said syndrome, disorder or disease is type II diabetes, obesity and asthma. The invention also comprises a method of inhibiting CCR2 activity in a mammal by administration of a therapeutically effective amount of at least one compound of Formula (I).

  本发明包括公式(I)的化合物。其中：R1、R2、R4、J、Q和A如说明书所述定义。本发明还包括预防、治疗或改善综合征、障碍或疾病的方法，其中所述综合征、障碍或疾病为2型糖尿病、肥胖和哮喘。本发明还包括通过管理治疗有效量的至少一种公式(I)化合物来抑制哺乳动物中的CCR2活性的方法。
• FOUR-RING LIQUID CRYSTAL COMPOUND HAVING LATERAL FLUORINE, LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL DISPLAY DEVICE
  申请人：Kobayashi Masahide

  公开号：US20110090450A1

  公开（公告）日：2011-04-21

  The invention provides a liquid crystal compound which has stability to heat, light and so forth, a nematic phase in a wide temperature range, a small viscosity, a large optical anisotropy, and a suitable elastic constant K 33 , and further has a suitable and negative dielectric anisotropy and an excellent compatibility with other liquid crystal compounds. Moreover, the invention provides a liquid crystal composition comprising this liquid crystal compound and a liquid crystal display device containing this liquid crystal composition. A liquid crystal compound represented by formula (a): for example, R 1 and R 2 are alkyl having 1 to 10 carbons, alkenyl having 2 to 10 carbons or alkoxy having 1 to 9 carbons; ring A 1 and ring A 2 are 1,4-phenylene or trans-1,4-cyclohexylene; L 1 and L 2 are hydrogen or fluorine, and at least one of L 1 and L 2 is fluorine; and Z 1 and Z 2 are a single bond, —(CH 2 ) 2 —, —CH═CH—, —CH 2 O— or —OCH 2 —.

  本发明提供一种液晶化合物，具有耐热、耐光等稳定性，在广泛的温度范围内具有向列相，粘度小，光学各向异性大，适当的弹性常数K33，进一步具有适当且负的介电各向异性，与其他液晶化合物具有良好的相容性。此外，本发明还提供了包含该液晶化合物的液晶组合物和包含该液晶组合物的液晶显示装置。一种由公式（a）表示的液晶化合物：例如，R1和R2是具有1至10个碳原子的烷基，具有2至10个碳原子的烯基或具有1至9个碳原子的烷氧基；环A1和环A2是1,4-苯撑基或反-1,4-环己撑基；L1和L2是氢或氟，且至少有一个是氟；Z1和Z2是单键，-(CH2)2-，-CH═CH-，- O-或-O -。
• CYCLOHEXYL-AZETIDINYL ANTAGONISTS OF CCR2
  申请人：Lanter James C.

  公开号：US20110312936A1

  公开（公告）日：2011-12-22

  The present invention comprises compounds of Formula I. wherein: R 1 , R 2 , R 4 , J, Q, and A are as defined in the specification. The invention also comprises a method of preventing, treating or ameliorating a syndrome, disorder or disease, wherein said syndrome, disorder or disease is type II diabetes, obesity and asthma. The invention also comprises a method of inhibiting CCR2 activity in a mammal by administration of a therapeutically effective amount of at least one compound of Formula I.

  本发明涉及I式化合物，其中：R1、R2、R4、J、Q和A如规范中所定义。本发明还涉及一种预防、治疗或改善综合症、紊乱或疾病的方法，其中所述综合症、紊乱或疾病是II型糖尿病、肥胖和哮喘。本发明还涉及通过给哺乳动物施加至少一种I式化合物的治疗有效量来抑制CCR2活性的方法。
• FOUR- OR FIVE-RING LIQUID CRYSTAL COMPOUND HAVING LATERAL FLUORINE, LIQUID CRYSTAL COMPOSITION, AND LIQUID CRYSTAL DISPLAY DEVICE
  申请人：Kobayashi Masahide

  公开号：US20100309402A1

  公开（公告）日：2010-12-09

  The invention provides a liquid crystal compound having stability to heat, light and so forth, a wide temperature range of a nematic phase, a small viscosity, a suitable optical anisotropy, and a suitable elastic constant K 33 , and further having a suitable and negative dielectric anisotropy and an excellent compatibility with other liquid crystal compounds, and a liquid crystal composition having stability to heat, light and so forth, a low viscosity, a large optical anisotropy, a suitable and negative dielectric anisotropy, and a suitable elastic constant K 33 , a low threshold voltage, a high maximum temperature (phase-transition temperature on a nematic phase-isotropic phase) of a nematic phase, and a low minimum temperature of the nematic phase. The liquid crystal compound which has a specific structure having fluorine at a lateral position and also having phenylene in which hydrogen on the benzene ring is replaced by fluorine, and a liquid crystal composition containing the compound are prepared.

  本发明提供了一种液晶化合物，具有耐热、耐光等稳定性，广泛的向列相温度范围，低粘度，适当的光学各向异性和适当的弹性常数K33，进一步具有适当且负的介电各向异性和与其他液晶化合物优异的相容性，以及一种液晶组合物，具有耐热、耐光等稳定性，低粘度，大的光学各向异性，适当且负的介电各向异性，适当的弹性常数K33，低阈值电压，向列相的高最大温度（向列相-等向相相变温度）和低向列相的最低温度。制备了一种具有侧位氟和苯环上氢被氟取代的苯基的特定结构的液晶化合物以及含有该化合物的液晶组合物。
• TETRACYCLIC LIQUID CRYSTALLINE COMPOUND HAVING LATERAL FLUORINE, LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL DISPLAY ELEMENT
  申请人：Chisso Corporation

  公开号：EP2305627A1

  公开（公告）日：2011-04-06

  The invention provides a liquid crystal compound which has stability to heat, light and so forth, a nematic phase in a wide temperature range, a small viscosity, a large optical anisotropy, and a suitable elastic constant K33, and further has a suitable and negative dielectric anisotropy and an excellent compatibility with other liquid crystal compounds. Moreover, the invention provides a liquid crystal composition comprising this liquid crystal compound and a liquid crystal display device containing this liquid crystal composition. A liquid crystal compound represented by formula (a): for example, R1 and R2 are alkyl having 1 to 10 carbons, alkenyl having 2 to 10 carbons or alkoxy having 1 to 9 carbons; ring A1 and ring A2 are 1, 4-phenylene or trans-1, 4-cyclohexylene; L1 and L2 are hydrogen or fluorine, and at least one of L1 and L2 is fluorine; and Z1 and Z2 are a single bond, -(CH2)2-, -CH=CH-, -CH2O- or -OCH2-.

  本发明提供了一种液晶化合物，它对热、光等具有稳定性，在较宽的温度范围内具有向 列相，粘度小，光学各向异性大，弹性常数 K33 合适，而且介电各向异性合适且为负，与其他液晶化合物具有良好的兼容性。此外，本发明还提供了一种包含这种液晶化合物的液晶组合物和一种包含这种液晶组合物的液晶显示设备。 由式(a)表示的液晶化合物： 例如，R1 和 R2 是具有 1 至 10 个碳原子的烷基、具有 2 至 10 个碳原子的烯基或具有 1 至 9 个碳原子的烷氧基；环 A1 和环 A2 是 1，4-亚苯基或反式-1，4-环己烯；L1 和 L2 是氢或氟，且 L1 和 L2 中至少有一个是氟；以及 Z1 和 Z2 是单键、-(CH2)2-、-CH=CH-、- O- 或 -O -。