4-i-Propoxy-β-picolin | 102439-27-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4-i-Propoxy-β-picolin
• 英文别名: 4-Isopropyloxy-β-picolin；4-isopropoxy-3-methyl-pyridine；3-Methyl-4-propan-2-yloxypyridine
• CAS: 102439-27-0
• 化学式: C₉H₁₃NO
• 分子量: 151.208
• InChiKey: VBUKITNYDFUAFZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  22.1
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• Process for preparing substituted 4-amino-1-(pyridylmethyl)piperidine and related compounds
  申请人：Peterson J. Matthew

  公开号：US20060094878A1

  公开（公告）日：2006-05-04

  Processes and intermediates for preparing substituted 4-amino-1-(pyridylmethyl)-piperidine and related compounds in high yield and high purity are described. The substituted 4-amino-1-(pyridylmethyl)piperidine and related compounds prepared by the described processes are useful as muscarinic receptor antagonists.

  描述了制备高产率和高纯度的取代4-氨基-1-(吡啶甲基)-哌啶和相关化合物的过程和中间体。由所述过程制备的取代4-氨基-1-(吡啶甲基)哌啶和相关化合物可用作毒蕈碱受体拮抗剂。
• Substituted 4-amino-1-(pyridylmethyl)piperidine and related compounds
  申请人：Mammen Mathai

  公开号：US20080091034A1

  公开（公告）日：2008-04-17

  This invention provides 4-amino-1-(pyridylmethyl)piperidine and related compounds and pharmaceutically acceptable salts thereof which are useful as muscarinic receptor antagonists. This invention also provides pharmaceutical compositions containing such compounds; processes and intermediates useful for preparing such compounds; and methods for treating disease conditions mediated by muscarinic receptors, such as overactive bladder, irritable bowel syndrome and chronic obstructive pulmonary disease, using such compounds.

  本发明提供了4-氨基-1-(吡啶甲基)哌啶及其相关化合物和药学上可接受的盐，它们可用作毒蕈碱受体拮抗剂。本发明还提供了含有这些化合物的制药组合物；用于制备这些化合物的有用中间体和过程；以及使用这些化合物治疗由毒蕈碱受体介导的疾病状态，例如过度活跃的膀胱、肠易激综合征和慢性阻塞性肺疾病的方法。
• SUBSTITUTED 4-AMINO-1-(PYRIDYLMETHYL) PIPERIDINE AS MUSCARINIC RECEPTOR ANTAGONISTS
  申请人：Theravance, Inc.

  公开号：EP1556372B1

  公开（公告）日：2007-05-30
• US7285564B2
  申请人：——

  公开号：US7285564B2

  公开（公告）日：2007-10-23
• US7572918B2
  申请人：——

  公开号：US7572918B2

  公开（公告）日：2009-08-11