2-{6-[((3R)oxolan-3-yl)amino]-2-chloropurin-9-yl}(4S,2R,3R,5R)-5-{[(propylamino)thioxomethoxy]methyl}oxolane-3,4-diol | 342419-69-6

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘌呤核苷
• 英文名称: 2-{6-[((3R)oxolan-3-yl)amino]-2-chloropurin-9-yl}(4S,2R,3R,5R)-5-{[(propylamino)thioxomethoxy]methyl}oxolane-3,4-diol
• 英文别名: O-[[(2R,3S,4R,5R)-5-[2-chloro-6-[[(3R)-oxolan-3-yl]amino]purin-9-yl]-3,4-dihydroxyoxolan-2-yl]methyl] N-propylcarbamothioate
• CAS: 342419-69-6
• 化学式: C₁₈H₂₅ClN₆O₅S
• 分子量: 472.953
• InChiKey: WDROSPSNPOIDCC-ZGOQAQPGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  31
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  168
• 氢给体数：
  4
• 氢受体数：
  10

文献信息

• Method of identifying partial adenosine A1 receptor agonists and their use in the treatment of arrhythmias
  申请人：——

  公开号：US20010008883A1

  公开（公告）日：2001-07-19

  The present invention provides a method for identifying parital adenosine A1 receptor agonists that are useful in the treatment of arrhythmias. Partial adenosine A1 receptor agonists and methods for using partial adenosine A1 receptor agonists to treat arrhythmias in mammals.

  本发明提供了一种用于识别对治疗心律失常有用的部分腺苷A1受体激动剂的方法。部分腺苷A1受体激动剂以及使用部分腺苷A1受体激动剂治疗哺乳动物心律失常的方法。
• US6576620B2
  申请人：——

  公开号：US6576620B2

  公开（公告）日：2003-06-10
• [EN] N<6> HETEROCYCLIC 5' MODIFIED ADENOSINE DERIVATIVES<br/>[FR] DERIVES D'ADENOSINE N<6> HETEROCYCLIQUES 5' MODIFIES
  申请人：CV THERAPEUTICS INC

  公开号：WO2001040244A1

  公开（公告）日：2001-06-07

  N6 heterocyclic 5' modified adenosine derivatives that are adenosine A¿1? receptor partial or full agonists, and as such, are useful for modifying cardiac activity, modifying adipocyte function, treating central nervous system disorders, and treating diabetic disorders and obesity in mammals, and especially in humans.