adenosin-5'-monophosphate | 53037-82-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: adenosin-5'-monophosphate
• 英文别名: 1-(7-amino-imidazo[4,5-b]pyridin-3-yl)-O⁵-phosphono-β-D-1-deoxy-ribofuranose；1-deaza-[5']adenylic acid；AMP；1-Deazaadenosine-5'-phosphate；1-Deazaadenosin-monophosphat；N1-deaza-adenosine-5'-monophosphate；[(2R,3S,4R,5R)-5-(7-aminoimidazo[4,5-b]pyridin-3-yl)-3,4-dihydroxyoxolan-2-yl]methyl dihydrogen phosphate
• CAS: 53037-82-4
• 化学式: C₁₁H₁₅N₄O₇P
• 分子量: 346.236
• InChiKey: MKNCBTMEOTYSIQ-PNHWDRBUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -3.2
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  173
• 氢给体数：
  5
• 氢受体数：
  10

反应信息

• 作为反应物：
  描述：

  Ru{N'-(2-hydroxyethyl)ethylenediamine-N,N,N'-triacetate}(H2O) 、 adenosin-5'-monophosphate 以 水 为溶剂， 生成 [Ru(N-hydroxyethylethylenediaminetriacetate)(adenosin-5'-monophosphate)]
  参考文献：
  名称：

  Reactivity of [RuIII(pac)(H2O)] (pac=polyaminocarboxylate) complexes with 5′-nucleotides and their antitumor activity

  摘要：

  The reaction of [Ru-III(edta)(H2O)](-) (edta(4-) = ethylenediaminetetriiacetate) and [Ru-III(hedtra)(H2O)] (hedtra(3) = N-hydroxyethylethylenediaminetriacetate) with various purine based 5'-nucleotides (Nu) viz. adenosin-5'-monophosphate (AMP), guanosin-5'-monophosphate (GMP), inosin-5'-monophosphate (IMP) was studied kinetically as a function of [Nu] at various temperatures (15-35 degrees C) at a fixed pH (4.5). Kinetic results suggest that the binding of 5'-nucleotides takes place in a rapid [Nu] dependent rate-determining step. Kinetic data and activation parameters are accounted for the operation of an associative mechanism. The antitumor activities of both [Ru-III(edta)(H2O](-) (1) and [Ru-III(hedtra)(H2O] (2) have been evaluated using MCF-7 (breast cancer), NCI-H460 (lung cancer) and SF-268 (CNS) cell lines. (c) 2004 Published by Elsevier B.V.

  DOI：

  10.1016/j.ica.2004.09.053

文献信息

• MODIFIED NUCLEOSIDES, NUCLEOTIDES, AND NUCLEIC ACIDS, AND USES THEREOF
  申请人：modeRNA Therapeutics

  公开号：US20130115272A1

  公开（公告）日：2013-05-09

  The present disclosure provides modified nucleosides, nucleotides, and nucleic acids, and methods of using them.
• METHOD FOR PRODUCING A PROTEIN OF INTEREST IN A PRIMATE
  申请人：MODERNA THERAPEUTICS

  公开号：US20130245104A1

  公开（公告）日：2013-09-19

  The present disclosure provides, inter alia, formulation compositions comprising modified nucleic acid molecules which may encode a protein, a protein precursor, or a partially or fully processed form of the protein or a protein precursor. The formulation composition may further include a modified nucleic acid molecule and a delivery agent. The present invention further provides nucleic acids useful for encoding polypeptides capable of modulating a cell's function and/or activity.
• MODIFIED POLYNUCLEOTIDES ENCODING COPPER METABOLISM (MURR1) DOMAIN CONTAINING 1
  申请人：Bancel Stephane

  公开号：US20140105965A1

  公开（公告）日：2014-04-17

  The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
• MODIFIED POLYNUCLEOTIDES FOR TREATING ARYLSULFATASE A PROTEIN DEFICIENCY
  申请人：MODERNA THERAPEUTICS, INC.

  公开号：US20140206755A1

  公开（公告）日：2014-07-24

  The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
• US20140255467A1
  申请人：——

  公开号：US20140255467A1

  公开（公告）日：2014-09-11