4'-(Hydroxymethyl)adenosin | 63070-09-7

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘌呤核苷
• 英文名称: 4'-(Hydroxymethyl)adenosin
• 英文别名: (3S,4R,5R)-5-(6-aminopurin-9-yl)-2,2-bis(hydroxymethyl)oxolane-3,4-diol
• CAS: 63070-09-7
• 化学式: C₁₁H₁₅N₅O₅
• 分子量: 297.271
• InChiKey: WBNQTEKLVXXLQW-MATHAZKKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.9
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  160
• 氢给体数：
  5
• 氢受体数：
  9

文献信息

• 2-(purin-9-yl)-tetrahydrofuran-3,4-diol derivatives
  申请人：——

  公开号：US20020086850A1

  公开（公告）日：2002-07-04

  There are provided according to the invention novel compounds of formula I 1 wherein R 1 , R 2 and R 3 are as described in the specification, processes for preparing them, formulations containing them and their use in therapy for the treatment of inflammatory diseases.

  根据本发明提供了一种新型化合物，其化学式为I1，其中R1、R2和R3如规范中所述，还提供了制备这些化合物的方法、含有它们的配方以及它们在治疗炎症性疾病中的用途。
• 2-(PURIN-9-yl)-TETRAHYDROFURAN-3,4-DIOL DERIVATIVES
  申请人：GLAXO GROUP LIMITED

  公开号：EP1051425B1

  公开（公告）日：2002-10-30
• 2-(PURIN-9-YL)-TETRAHYDROFURAN-3,4-DIOL DERIVATIVES
  申请人：GLAXO GROUP LIMITED

  公开号：EP1090020B1

  公开（公告）日：2003-11-05
• 4'-SUBSTITUTED NUCLEOSIDE DERIVATIVES AS INHIBITORS OF HCV RNA REPLICATION
  申请人：Devos Rene Robert

  公开号：US20100003213A1

  公开（公告）日：2010-01-07

  The present invention relates to the use of nucleoside derivatives of formula Ia wherein the symbols are as defined in the specification, and of pharmaceutically acceptable salts thereof and to pharmaceutical compositions containing such compounds.
• 4'-Substituted Nucleoside Derivatives as Inhibitors of HCV RNA Replication
  申请人：Martin Joseph Armstrong

  公开号：US20100004192A1

  公开（公告）日：2010-01-07

  The present invention relates to the use of nucleoside derivatives of formula Ia wherein the symbols are as defined in the specification, and of pharmaceutically acceptable salts thereof and to pharmaceutical compositions containing such compounds.