N-(2-(dimethylamino)ethyl)laurylamide | 56905-26-1

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: N-(2-(dimethylamino)ethyl)laurylamide
• 英文别名: N-(2-(dimethylamino)ethyl)lauramide；N-(2-dimethylamino-ethyl)-lauramide；N-(2-Dimethylamino-aethyl)-lauramid；dodecanoic acid (2-dimethylaminoethyl)-amide；N-(2-(Dimethylamino)-ethyl)-lauramide；N-[2-(dimethylamino)ethyl]dodecanamide
• CAS: 56905-26-1
• 化学式: C₁₆H₃₄N₂O
• 分子量: 270.459
• InChiKey: KXFJXWOTQMPQNI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  19
• 可旋转键数：
  13
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.94
• 拓扑面积：
  32.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N-(2-(dimethylamino)ethyl)laurylamide 生成 Dodecanamide, N-(2-(dimethyloxidoamino)ethyl)-
  参考文献：
  名称：

  DEVINSKY, F.;LACKO, I.;KRASNEC, L.;SIGMUNDOVA, I.

  摘要：

  DOI：
• 作为产物：
  描述：

  月桂酸 在 氯化亚砜 、 三乙胺 作用下， 以 二氯甲烷 、 甲苯 为溶剂， 生成 N-(2-(dimethylamino)ethyl)laurylamide
  参考文献：
  名称：

  含两个酰胺官能团的三阳离子表面活性剂的合成及其在酸性介质中对金属腐蚀的缓蚀作用

  摘要：

  在这项研究中，合成了两种含有两个酰胺官能团和三个带正电荷的季铵氮的三阳离子表面活性剂。合成的表面活性剂的结构通过各种光谱方法（FT-IR，1 H NMR，和13C核磁共振）。在 1.0 M HCl 酸性介质中使用失重法测定两种合成产物对低碳钢腐蚀的抑制活性。通过在室温下将金属试片浸入不同抑制剂浓度的酸性溶液中 24 小时进行腐蚀试验，两种表面活性剂均获得了紧密有效的抑制作用。已发现其结构中长碳链中的碳数是防腐蚀的有效因素。在酸性环境中，长链含碳量较多的缓蚀剂的缓蚀效率略高于其他缓蚀剂。而在其长链中含有 16 个碳原子的化合物显示出超过 92% 的腐蚀抑制，在其长链中含有 12 个碳的化合物表现出 90% 及以下的腐蚀抑制。此外，计算了三阳离子表面活性剂的一些物理化学参数，如临界胶束浓度、该浓度下的表面张力和胶束形成的自由能，以便将它们与其抗腐蚀活性相关联。还通过扫描电子显微镜拍摄表面图像，

  DOI：

  10.1002/jsde.12614

文献信息

• Hair Growth Regulating Agent
  申请人：Suzuki Yasuto

  公开号：US20110130456A1

  公开（公告）日：2011-06-02

  A hair growth regulating agent containing, as an active ingredient, a compound represented by the following formula (I): [wherein R1 represents a substituted or unsubstituted, linear or branched C2 to C25 alkyl group; a group represented by the following formula (II): (wherein R1′ represents a substituted or unsubstituted, linear or branched C2 to C20 alkylene group, or —(CH2)n-O—(CH2)m}o-O—(CH2)p- in which each of n, m, o, and p is an integer from 1 to 6; X′ represents —CO—NH—, —O—CO—O—, —NH—CO—, —CO—O—, —O—CO—, or —O—; Y′ represents a substituted or unsubstituted C1 to C4 alkylene group; R2′ represents a hydrogen atom or a C1 to C4 alkyl group; R3′ represents a C1 to C4 alkyl group; and when R2′ and R3′ each represent a C1 to C4 alkyl group, the two alkyl groups may be identical to or different from each other); or a group represented by the following formula (III): (wherein R1′, X′, and Y′ have the same meanings as defined above; R4′, R5′, and R6′, which may be identical to or different from one another, each represent a C1 to C4 alkyl group; and A′- represents a counter ion); X represents —CO—NH—, —O—CO—O—, —NH—CO—, —CO—O—, —O—CO—, or —O—; Y represents a substituted or unsubstituted C1 to C4 alkylene group; R2 represents a hydrogen atom or a C1 to C4 alkyl group; R3 represents a C1 to C4 alkyl group; and when R2 and R3 each represent a C1 to C4 alkyl group, the two alkyl groups may be identical to or different from each other] or a salt of the compound; and/or a quaternary ammonium salt represented by the following formula (IV): (wherein R1, X, and Y have the same meanings as defined above; R4, R5, and R6, which may be identical to or different from one another, each represent a C1 to C4 alkyl group; and A- represents a counter ion).

  一种含有以下式（I）所代表的化合物作为活性成分的头发生长调节剂：[其中R1代表取代或未取代的直链或支链C2至C25烷基团；由以下式（II）表示的基团：（其中R1'代表取代或未取代的直链或支链C2至C20烷基烯基团，或者—（CH2）n-O—（CH2）m}o-O—（CH2）p-，其中n，m，o和p中的每个都是1至6的整数；X'代表—CO—NH—，—O—CO—O—，—NH—CO—，—CO—O—，—O—CO—或—O—；Y'代表取代或未取代的C1至C4烷基烯基团；R2'代表氢原子或C1至C4烷基团；R3'代表C1至C4烷基团；当R2'和R3'各自代表C1至C4烷基团时，这两个烷基团可以相同或不同）；或由以下式（III）表示的基团：（其中R1'，X'和Y'的含义与上述定义相同；R4'，R5'和R6'，可以相同也可以不同，各代表C1至C4烷基团；A'-代表一个对离子）；X代表—CO—NH—，—O—CO—O—，—NH—CO—，—CO—O—，—O—CO—或—O—；Y代表取代或未取代的C1至C4烷基烯基团；R2代表氢原子或C1至C4烷基团；R3代表C1至C4烷基团；当R2和R3各自代表C1至C4烷基团时，这两个烷基团可以相同或不同]或该化合物的盐；和/或由以下式（IV）所代表的季铵盐：（其中R1，X和Y的含义与上述定义相同；R4，R5和R6，可以相同也可以不同，各代表C1至C4烷基团；A-代表一个对离子）。
• Design, synthesis, antibacterial activity and toxicity of novel quaternary ammonium compounds based on pyridoxine and fatty acids
  作者：Sergey V. Sapozhnikov、Alina E. Sabirova、Nikita V. Shtyrlin、Anastasia Y. Druk、Mariya N. Agafonova、Milana N. Chirkova、Renata R. Kazakova、Denis Y. Grishaev、Tatyana V. Nikishova、Elena S. Krylova、Elena V. Nikitina、Airat R. Kayumov、Yurii G. Shtyrlin

  DOI：10.1016/j.ejmech.2020.113100

  日期：2021.2

  membrane suggesting that the membrane is an apparent molecular target of compounds. 6i and 12a were non mutagenic neither in SOS-chromotest nor in Ames test and non-toxic in vivo at acute oral (LD50 > 2000 mg/kg) and cutaneous administration (LD50 >2500 mg/kg) on mice. Taken together, our data allow suggesting the described active compounds as promising starting point for the new antibacterial agents development

  设计了一系列基于季铵吡ido醇衍生物的43种新颖的“软抗菌剂”，其中包括吡soft醇的六元缩醛和缩酮，它们通过可裂解的连接基部分（酰胺，酯）与脂肪羧酸的片段结合。九种化合物对革兰氏阳性和革兰氏阴性细菌菌株具有体外有望的抗菌活性，其MIC值可与参考防腐剂miramistin，苯扎氯铵和氯己定相比。在各种临床分离株上，先导化合物6i和12a表现出与苯扎氯铵相当的抗菌活性，但比miramistin高。此外，6i和12a能够杀死嵌入单物种和双物种生物膜基质中的细菌。用6i和12a处理细菌细胞会导致膜快速去极化，表明该膜是化合物的明显分子靶标。6i和12a在SOS-chromotest和Ames试验中均无致突变性，并且在小鼠急性口服（LD 50 > 2000 mg / kg）和经皮给药（LD 50 > 2500 mg / kg）时体内无毒。综上所述，我们的数据可以表明所描述的活性化合物是新抗菌剂开发的有希望的起点。
• [EN] NOVEL METHOD TO MANUFACTURE SURFACE ACTIVE COMPOUNDS SUCH AS SULFATE BETAINE<br/>[FR] NOUVEAU PROCÉDÉ DE FABRICATION DE COMPOSÉS TENSIO-ACTIFS TELS QUE LE SULFATE BÉTAÏNE
  申请人：RHODIA OPERATIONS

  公开号：WO2013067915A1

  公开（公告）日：2013-05-16

  The present invention relates generally to novel methods of preparing compounds such as sulfate betaines by reacting an amine with a cyclic (poly)glycerol sulphate (CGS) compound and the compound such as sulfate betaine products obtained by using the same.

  本发明通常涉及通过将胺与环状（聚）甘油硫酸酯（CGS）化合物反应来制备硫酸盐甜菜碱等化合物的新方法，以及利用这些方法获得的硫酸盐甜菜碱等化合物产品。
• Composition for External Application to Skin
  申请人：Suzuki Yasuto

  公开号：US20100273875A1

  公开（公告）日：2010-10-28

  A composition for external application to skin, containing a compound represented by formula (I) or a salt thereof, and/or a quaternary ammonium salt represented by formula (II): wherein R 1 is a substituted or unsubstituted, linear or branched chain alkyl group having 2 to 25 carbon atoms; X is —CO—NH—, —O—CO—O—, —NH—CO—, —CO—O—, —O—CO— or —O—; Y is a substituted or unsubstituted alkylene group having 1 to 4 carbon atoms; R 2 is a hydrogen atom or an alkyl group having 1 to 4 carbon atoms; R 3 is an alkyl group having 1 to 4 carbon atoms; R 2 and R 3 are the same as or different from each other; R 4 , R 5 and R 6 , which may the same as or different from each other, each are an alkyl group having 1 to 4 carbon atoms; and A − is a counter ion.

  一种用于外用于皮肤的组合物，含有由式（I）或其盐所代表的化合物和/或由式（II）所代表的季铵盐：其中，R1是具有2到25个碳原子的取代或未取代的线性或支链烷基；X是-CO-NH-，-O-CO-O-，-NH-CO-，-CO-O-，-O-CO-或-O-；Y是具有1到4个碳原子的取代或未取代的亚烷基基团；R2是氢原子或具有1到4个碳原子的烷基基团；R3是具有1到4个碳原子的烷基基团；R2和R3相同或不同；R4、R5和R6，它们可以相同也可以不同，每个都是具有1到4个碳原子的烷基基团；A-是一个反离子。
• Method of improving the electrical conductivity of a molding artcile of resin, method of coating a molding article of resin, and coating composition
  申请人：NIPPON PAINT CO., LTD.

  公开号：EP0764663A2

  公开（公告）日：1997-03-26

  There is provided a method for coating a molded resin article such as an automotive part, and improving its electrical conductivity by a high productivity procedure which avoids using an inorganic conductive primer. The substrate is coated with a composition containing a film-forming component and a specified nitrogen-containing compound and the coated surface is subjected to corona discharge treatment and is then optionally electrostatically coated.

  本发明提供了一种涂覆模塑树脂制品（如汽车零件）的方法，该方法采用高生产率程序，避免使用无机导电底漆，从而提高了其导电性。在基材上涂覆一种含有成膜成分和特定含氮化合物的组合物，然后对涂覆表面进行电晕放电处理，再选择性地进行静电涂覆。