Dodecanamide, N-(2-(dimethyloxidoamino)ethyl)- | 86321-42-8

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: Dodecanamide, N-(2-(dimethyloxidoamino)ethyl)-
• 英文别名: 2-(dodecanoylamino)-N,N-dimethylethanamine oxide
• CAS: 86321-42-8
• 化学式: C16H34N2O2
• 分子量: 286.45
• InChiKey: YWBRLYMOWANDKF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  20
• 可旋转键数：
  13
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.94
• 拓扑面积：
  47.2
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  N-(2-(dimethylamino)ethyl)laurylamide 生成 Dodecanamide, N-(2-(dimethyloxidoamino)ethyl)-
  参考文献：
  名称：

  DEVINSKY, F.;LACKO, I.;KRASNEC, L.;SIGMUNDOVA, I.

  摘要：

  DOI：

文献信息

• POLYETHER-MODIFIED ORGANOPOLYSILOXANE, DIORGANOPOLYSILOXANE-POLYETHER BLOCK COPOLYMER, THEIR PRODUCTION METHODS, AND COSMETIC PREPARATION
  申请人：Dow Corning Toray Co., Ltd.

  公开号：EP2022812A1

  公开（公告）日：2009-02-11

  (Problem) To provide a novel polyether-modified organopolysiloxane and a novel diorganopolysiloxane-polyether block copolymer that are more resistant to oxidation than the heretofore existing polyoxyalkylene-modified organopolysiloxanes and that are thus more resistant to producing allergenically antigenic oxidation products during elapsed time in storage. Also, to provide methods of producing this novel polyether-modified organopolysiloxane and novel diorganopolysiloxane-polyether block copolymer. (Solution) Organopolysiloxane that is modified by silicon-bonded polyglycidyl ether or glycidyl ether/alkylene oxide copolymer; diorganopolysiloxane-polyglycidyl ether block copolymer; a method of producing the preceding by a hydrosilylation reaction between organohydrogenpolysiloxane and polyglycidyl ether having a terminal double bond or a glycidyl ether/alkylene oxide copolymer having a terminal double bond; and a cosmetic that contains this modified organopolysiloxane or diorganopolysiloxane-polyglycidyl ether block copolymer.

  问题 提供一种新型聚醚改性有机聚硅氧烷和一种新型二甘醇聚硅氧烷-聚醚嵌段共聚物，它们比现有的聚氧亚烷基改性有机聚硅氧烷更耐受氧化，因此在储存过程中更不易产生致敏抗原氧化产物。同时，提供生产这种新型聚醚改性有机聚硅氧烷和新型二异甘聚硅氧烷-聚醚嵌段共聚物的方法。 (解决方案） 由硅键聚缩水甘油醚或缩水甘油醚/环氧丙烷共聚物改性的有机聚硅氧烷；二甘醇聚硅氧烷-聚缩水甘油醚嵌段共聚物；一种通过有机氢聚硅氧烷和具有末端双键的聚缩水甘油醚或具有末端双键的缩水甘油醚/环氧烷共聚物之间的氢硅烷化反应生产前述物质的方法；以及一种含有这种改性有机聚硅氧烷或二甘聚硅氧烷-聚缩水甘油醚嵌段共聚物的化妆品。
• High concentration formulations of adalimumab
  申请人：Coherus Biosciences, Inc.

  公开号：US11229702B1

  公开（公告）日：2022-01-25

  The present invention relates to aqueous pharmaceutical compositions comprising a high concentration (i.e., greater than 50 milligrams per milliliter) of adalimumab (including antibody proteins considered or intended as “biosimilar” or “bio-better” variants of commercially available adalimumab) suitable for long-term storage, and methods of manufacture of the compositions; methods of their administration; and articles containing the same.

  本发明涉及包含适合长期储存的高浓度（即每毫升大于 50 毫克）阿达木单抗（包括被认为或打算作为市售阿达木单抗的 "生物类似物 "或 "生物更优 "变体的抗体蛋白）的水性药物组合物，以及该组合物的制造方法、给药方法和含有该组合物的物品。
• DEVINSKY, F.;LACKO, I.;KRASNEC, L.;SIGMUNDOVA, I.
  作者：DEVINSKY, F.、LACKO, I.、KRASNEC, L.、SIGMUNDOVA, I.

  DOI：——

  日期：——
• STABLE PHARMACEUTICAL COMPOSITION, COMPRISING AN AQUEOUS SOLUTION OF AN ANTIBODY-DERIVED THERAPEUTICALLY ACTIVE PROTEIN
  申请人：Adocia

  公开号：EP2897587A1

  公开（公告）日：2015-07-29
• Polyether-Modified Organopolysiloxane, Diorganopolysiloxane-Polyether Block Copolymer, Their Production Methods, and Cosmetic Preparation
  申请人：Okawa Tadashi

  公开号：US20100036062A1

  公开（公告）日：2010-02-11

  (Problem) To provide a novel polyether-modified organopolysiloxane and a novel diorganopolysiloxane-polyether block copolymer that are more resistant to oxidation than the heretofore existing polyoxyalkylene-modified organopolysiloxanes and that are thus more resistant to producing allergenically antigenic oxidation products during elapsed time in storage. Also, to provide methods of producing this novel polyether-modified organopolysiloxane and novel diorganopolysiloxane-polyether block copolymer. (Solution) Organopolysiloxane that is modified by silicon-bonded polyglycidyl ether or glycidyl ether/alkylene oxide copolymer; diorganopolysiloxane-polyglycidyl ether block copolymer; a method of producing the preceding by a hydrosilylation reaction between organohydrogenpolysiloxane and polyglycidyl ether having a terminal double bond or a glycidyl ether/alkylene oxide copolymer having a terminal double bond; and a cosmetic that contains this modified organopolysiloxane or diorganopolysiloxane-polyglycidyl ether block copolymer.