4-氯-2-甲基丁烷-2,3-二醇 | 134878-48-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 4-氯-2-甲基丁烷-2,3-二醇
• 英文名称: 4-chloro-2-methylbutane-2,3-diol
• 英文别名: 1-Chloro-3-methylbutane-2,3-diol
• CAS: 134878-48-1
• 化学式: C₅H₁₁ClO₂
• mdl: MFCD19233754
• 分子量: 138.594
• InChiKey: DLCRLZSIWCNHTQ-UHFFFAOYSA-N

物化性质

• 沸点：
  257.7±20.0 °C(Predicted)
• 密度：
  1.175±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  8
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  40.5
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2-(oxiran-2-yl)propan-2-ol 在 sodium azide 、 氯化二乙基铝 作用下， 以 甲苯 为溶剂， 以62%的产率得到1-Azido-3-methylbutane-2,3-diol
  参考文献：
  名称：

  Regio- and stereoselective ring opening of 2,3-epoxyalcohols with diethylaluminium azide

  摘要：

  2,3-Epoxyalcohols react with diethylaluminium azide under mild conditions to give 3-azido-1,2-diols resulting from the regio- and stereoselective attack of the nucleophile at the epoxide C-3. The high regioselectivity (>25:1) observed with both cis and trans substituted epoxides is not affected by bulky substituents at C-3. The method has been successfully applied also to the synthesis of diaminodiol dipeptide isosteres, (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(98)01733-x

文献信息

• Bentley, Stuart; Goosen, Andre; Laue, Hugh A. H., Journal of Chemical Research, Miniprint, 1991, p. 1566 - 1590
  作者：Bentley, Stuart、Goosen, Andre、Laue, Hugh A. H.、Taljaard, Benjamin

  DOI：——

  日期：——
• Regio- and stereoselective ring opening of 2,3-epoxyalcohols with diethylaluminium azide
  作者：Fabio Benedetti、Federico Berti、Stefano Norbedo

  DOI：10.1016/s0040-4039(98)01733-x

  日期：1998.10

  2,3-Epoxyalcohols react with diethylaluminium azide under mild conditions to give 3-azido-1,2-diols resulting from the regio- and stereoselective attack of the nucleophile at the epoxide C-3. The high regioselectivity (>25:1) observed with both cis and trans substituted epoxides is not affected by bulky substituents at C-3. The method has been successfully applied also to the synthesis of diaminodiol dipeptide isosteres, (C) 1998 Elsevier Science Ltd. All rights reserved.