tert-butyl 4-Fluoro-4-nitro-4-phenylbutanoate | 1423065-72-8

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: tert-butyl 4-Fluoro-4-nitro-4-phenylbutanoate
• CAS: 1423065-72-8
• 化学式: C₁₄H₁₈FNO₄
• 分子量: 283.3
• InChiKey: AOIFNTHTVWZIBO-UHFFFAOYSA-N

反应信息

• 作为产物：
  描述：

  1-fluoro-1-phenylnitromethane 、 丙烯酸叔丁酯 在 [RuH2(PPh3)4] 作用下， 以 乙腈 为溶剂， 反应 22.0h， 以80%的产率得到tert-butyl 4-Fluoro-4-nitro-4-phenylbutanoate
  参考文献：
  名称：

  [RuH2(PPh3)4]-Catalyzed Michael Addition Reaction of α-Fluoronitroalkanes

  摘要：

  The Michael addition reactions of alpha-fluoronitroalkanes with various electron-deficient olefins were realized by catalysis of low-valence ruthenium species through C-sp3-H activation, providing a useful way to construct a fluorinated quaternary carbon center. The reactions were carried out under neutral conditions, affording the desired products in moderate to excellent yields.

  DOI：

  10.1055/s-0032-1317526