6,7-dihydro-5H-pyrazolo[5,1-b][1,3]oxazine-3-carbaldehyde | 1706433-45-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 6,7-dihydro-5H-pyrazolo[5,1-b][1,3]oxazine-3-carbaldehyde
• CAS: 1706433-45-5
• 化学式: C₇H₈N₂O₂
• 分子量: 152.15
• InChiKey: UCVIPYQHTWRTBR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  44.1
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• INHIBITORS OF APOL1 AND METHODS OF USING SAME
  申请人：Vertex Pharmaceuticals Incorporated

  公开号：US20220106327A1

  公开（公告）日：2022-04-07

  The disclosure provides at least one entity chosen from compounds of Formula I, a tautomer thereof, a deuterated derivative of that compound or tautomer, and a pharmaceutically acceptable salt of any of the foregoing, compositions comprising the same, and methods of using the same, including uses in treating APOL1-mediated diseases, including pancreatic cancer, focal segmental glomerulosclerosis (FSGS), and/or non-diabetic kidney disease (NDKD).