(2R,3R,4R,5E/Z)-1,3,4-tribenzyloxy-5-pentadecene-2-ol | 164988-62-9

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: (2R,3R,4R,5E/Z)-1,3,4-tribenzyloxy-5-pentadecene-2-ol
• CAS: 164988-62-9
• 化学式: C₃₆H₄₈O₄
• 分子量: 544.775
• InChiKey: YYMUUPHYEBLMBW-LBYVEUBFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.43
• 重原子数：
  40.0
• 可旋转键数：
  21.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  47.92
• 氢给体数：
  1.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  (2R,3R,4R,5E/Z)-1,3,4-tribenzyloxy-5-pentadecene-2-ol 在 palladium on activated charcoal 氢气 作用下， 以 四氢呋喃 为溶剂， 反应 16.0h， 生成 (2R,3S,4R)-1,3,4-tris(phenylmethoxy)pentadecan-2-ol
  参考文献：
  名称：

  Structure-Activity Relationship of .alpha.-Galactosylceramides against B16-Bearing Mice

  摘要：

  Agelasphin-9b, (2S,3S,4R)-1-O-(alpha-D-galactopyranosyl)-16-methyl-2-[N-((R)-2-hydroxytetracosanoyl)-amino]-1,3,4-heptadecanetriol, is a potent antitumor agent isolated from the marine sponge Agelas mauritianus. Various analogues of agelasphin-9b (a lead compound) were synthesized, and the relationship between their structures and biological activities was examined using several assay systems. From the results, KRN7000, (2S,3S;4R)-1-O-(alpha-D-galactopyranosyl)2-(N-hexacosanoylamino)-1,3,4-octadecanetriol, was selected as a candidate for clinical application.

  DOI：

  10.1021/jm00012a018
• 作为产物：
  描述：

  3,4,5-tri-O-benzyl-D-galactopyranose 在 sodium periodate 、 正丁基锂 作用下， 以 乙醇 、 水 为溶剂， 反应 32.5h， 生成 (2R,3R,4R,5E/Z)-1,3,4-tribenzyloxy-5-pentadecene-2-ol
  参考文献：
  名称：

  Structure-Activity Relationship of .alpha.-Galactosylceramides against B16-Bearing Mice

  摘要：

  Agelasphin-9b, (2S,3S,4R)-1-O-(alpha-D-galactopyranosyl)-16-methyl-2-[N-((R)-2-hydroxytetracosanoyl)-amino]-1,3,4-heptadecanetriol, is a potent antitumor agent isolated from the marine sponge Agelas mauritianus. Various analogues of agelasphin-9b (a lead compound) were synthesized, and the relationship between their structures and biological activities was examined using several assay systems. From the results, KRN7000, (2S,3S;4R)-1-O-(alpha-D-galactopyranosyl)2-(N-hexacosanoylamino)-1,3,4-octadecanetriol, was selected as a candidate for clinical application.

  DOI：

  10.1021/jm00012a018

文献信息

• Sex Pheromones of the Hair Crab <i>Erimacrus </i><i>i</i><i>senbeckii</i>. II. Synthesis of Ceramides
  作者：Naoki Asai、Nobuhiro Fusetani、Shigeki Matsunaga

  DOI：10.1021/np010177m

  日期：2001.9.1

  To confirm their structures and to assess the pheromonal activity, novel ceramides, possible sex pheromones of the hair crab Erimacrus isenbeckii, were synthesized from D-galactose. The synthetic ceramides were identical with the natural ceramides.