4-[3-[[(2S)-4-acetylmorpholin-2-yl]methyl]-7-methylimidazo[1,2-a]pyridin-2-yl]-N-ethyl-3-methylbenzamide | 1621164-96-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 4-[3-[[(2S)-4-acetylmorpholin-2-yl]methyl]-7-methylimidazo[1,2-a]pyridin-2-yl]-N-ethyl-3-methylbenzamide
• CAS: 1621164-96-2
• 化学式: C₂₅H₃₀N₄O₃
• 分子量: 434.538
• InChiKey: XFDUQBZFVKTYSU-FQEVSTJZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  32
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  75.9
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• Imidazopyridine Compounds and Uses Thereof
  申请人：NEOMED INSTITUTE

  公开号：US20150361078A1

  公开（公告）日：2015-12-17

  This invention generally relates to substituted imidazopyridine compounds, particularly substituted 4-(imidazo[1,2-a]pyridin-2-yl)benzamide compounds and salts thereof. This invention also relates to pharmaceutical compositions and kits comprising such a compound, uses of such a compound (including, for example, treatment methods and medicament preparations), processes for making such a compound, and intermediates used in such processes.

  该发明通常涉及取代咪唑吡啶化合物，特别是取代的4-(咪唑[1,2-a]吡啶-2-基)苯甲酰胺化合物及其盐。该发明还涉及包含该化合物的药物组合物和试剂盒，以及该化合物的用途（包括治疗方法和药物制剂等），制备该化合物的过程以及用于该过程的中间体。
• IMIDAZOPYRIDINE COMPOUNDS AND USES THEREOF
  申请人：Bellus Health Cough Inc.

  公开号：EP3381917B1

  公开（公告）日：2021-09-08
• SELECTIVE P2X3 MODULATORS
  申请人：BELLUS HEALTH COUGH INC.

  公开号：US20200230148A1

  公开（公告）日：2020-07-23

  The current application relates to the use of a selective P2X3 antagonist for avoiding loss of taste response while treating a chronic cough in warm-blooded animals; wherein said selective P2X3 antagonist is selective for P2X3 homomeric receptor antagonism versus P2X2/3 heteromeric receptor antagonism.
• TREATMENT WITH P2X3 MODULATORS
  申请人：BELLUS HEALTH COUGH INC.

  公开号：US20210386751A1

  公开（公告）日：2021-12-16

  Provided herein are methods for treating endometriosis, endometriosis-associated pain, and endometriosis-associated symptoms in a mammal in need thereof with a P2X3 modulator.
• US9598409B2
  申请人：——

  公开号：US9598409B2

  公开（公告）日：2017-03-21