磺胺甲基嘧啶钠 | 127-58-2

• 物质功能分类: 原料药 - 人工合成抗感染类药 - 磺胺类药及增效剂
• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 磺胺甲基嘧啶钠
• 中文别名: 4-氨基-N-(4-甲基-2-嘧啶基)苯磺酰胺；磺胺甲嘧啶钠
• 英文名称: Benzenesulfonamide, 4-amino-N-(4-methyl-2-pyrimidinyl)-, sodium salt (1:1)
• CAS: 127-58-2
• 化学式: C11H12N4NaO2S
• 分子量: 287.3
• InChiKey: XEAKUBSUGWQDRM-UHFFFAOYSA-N

物化性质

• 溶解度：
  溶于二甲基亚砜

计算性质

• 辛醇/水分配系数(LogP)：
  0.79
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  106
• 氢给体数：
  2
• 氢受体数：
  6

安全信息

• TSCA：
  Yes
• 危险品标志：
  Xn
• 安全说明：
  S24,S45,S7
• 危险类别码：
  R20/22
• WGK Germany：
  3

制备方法与用途

用途

磺胺甲基嘧啶钠涉及用于药物运输的壳聚糖膜的表征。

生物活性

Sulfamerazine（RP-2632）钠盐是一种磺胺类抗菌素。

文献信息

• Process for formulating a medicated animal feed premix
  申请人：ELI LILLY AND COMPANY

  公开号：EP0060680A1

  公开（公告）日：1982-09-22

  A process of formulating a medicated animal feed premix comprising a synthetic drug, carrier and binder, for the purpose of reducing carryover of the synthetic drug to subsequent lots of animal feed processed in the feed mill.

  一种由合成药物、载体和粘合剂组成的药物动物饲料预混料的配制工艺，目的是减少合成药物在饲料厂加工的后续批次动物饲料中的残留。
• PARASITE CONTROL AGENT FOR FISH, AND PARASITE CONTROL METHOD FOR FISH
  申请人：Nippon Suisan Kaisha, Ltd.

  公开号：EP2213169A1

  公开（公告）日：2010-08-04

  An antiparasitic agent for fish containing an inhibitor of folate synthesis and/or an inhibitor of folate activation as the active substance(s). A combination preparation composed of an inhibitor of folate synthesis and an inhibitor of folate activation is preferable, and a sulfonamide is preferable for the inhibitor of folate synthesis. A dihydrofolate reductase inhibitor, a folate antagonist, etc., can be used as the inhibitor of folate activation. The antiparasitic agent is able to exterminate fish parasites via oral administration. It is particularly effective against parasites belonging to the ciliate group among fish parasites.

  一种鱼类抗寄生虫药剂，其活性物质含有叶酸合成抑制剂和/或叶酸活化抑制剂。最好是由叶酸合成抑制剂和叶酸活化抑制剂组成的组合制剂，叶酸合成抑制剂最好是磺胺类。叶酸活化抑制剂可使用二氢叶酸还原酶抑制剂、叶酸拮抗剂等。 抗寄生虫药剂能够通过口服消灭鱼类寄生虫。它对鱼类寄生虫中属于纤毛虫类的寄生虫特别有效。
• ANTIPARASITIC AGENT FOR FISH AND METHOD OF CONTROLLING PROLIFERATION OF FISH PARASITES
  申请人：Nippon Suisan Kaisha, Ltd.

  公开号：EP2425857A1

  公开（公告）日：2012-03-07

  A method of controlling proliferation of fish parasites comprising the administration of 1 to 50 mg/kg fish body weight/day of an inhibitor of folate synthesis and/or an inhibitor of folate activation to fish continuously for 1 to 2 weeks. Using a combination preparation composed of an inhibitor of folate synthesis and an inhibitor of folate activation is preferable, and a sulfonamide is preferable for the inhibitor of folate synthesis. A dihydrofolate reductase inhibitor, a folate antagonist, etc., can be used as the inhibitor of folate activation. The antiparasitic agent is able to exterminate fish parasites via oral administration. It is particularly effective against parasites belonging to the ciliate group among fish parasites.

  一种控制鱼类寄生虫增殖的方法，包括在 1 至 2 周内连续给鱼服用 1 至 50 毫克/千克鱼体重/天的叶酸合成抑制剂和/或叶酸活化抑制剂。最好使用由叶酸合成抑制剂和叶酸活化抑制剂组成的组合制剂，叶酸合成抑制剂最好使用磺胺类药物。叶酸活化抑制剂可使用二氢叶酸还原酶抑制剂、叶酸拮抗剂等。抗寄生虫药剂能够通过口服消灭鱼类寄生虫。它对鱼类寄生虫中属于纤毛虫类的寄生虫特别有效。
• VACCINE FOR IMMUNIZING CATS AGAINST TOXOPLASMA OOCYST SHEDDING
  申请人：THE UNIVERSITY OF KANSAS

  公开号：EP0485388A1

  公开（公告）日：1992-05-20
• EP0485388A4
  申请人：——

  公开号：EP0485388A4

  公开（公告）日：1993-02-10