(5,6-dihydroxy-2-(2-(trifluoromethyl)benzyl)pyrimidin-4-yl)(2-methoxyphenyl)methanone | 1407170-66-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (5,6-dihydroxy-2-(2-(trifluoromethyl)benzyl)pyrimidin-4-yl)(2-methoxyphenyl)methanone
• 英文别名: 5-hydroxy-4-(2-methoxybenzoyl)-2-[[2-(trifluoromethyl)phenyl]methyl]-1H-pyrimidin-6-one
• CAS: 1407170-66-4
• 化学式: C₂₀H₁₅F₃N₂O₄
• 分子量: 404.345
• InChiKey: WDUCPKMDQZNVPV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  29
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  88
• 氢给体数：
  2
• 氢受体数：
  8

文献信息

• [EN] PYRIMIDINONE COMPOUNDS AND METHODS FOR PREVENTING AND TREATING INFLUENZA<br/>[FR] COMPOSÉS DE PYRIMIDINONE ET MÉTHODES DE PRÉVENTION ET DE TRAITEMENT DE LA GRIPPE
  申请人：ST JUDE CHILDRENS RES HOSPITAL

  公开号：WO2012151567A1

  公开（公告）日：2012-11-08

  In one aspect, the invention relates to novel, broad-spectrum anti-viral, pyrimidinone compounds, methods of use, compositions and kits useful in treating and/or preventing influenza. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

  在一个方面，该发明涉及新颖的、广谱抗病毒的嘧啶酮化合物，以及用于治疗和/或预防流感的方法、组合物和工具包。本摘要旨在作为在特定领域进行搜索的扫描工具，并不意味着对本发明的限制。
• PYRIMIDINONE COMPOUNDS AND METHODS FOR PREVENTING AND TREATING INFLUENZA
  申请人：Webb Thomas R.

  公开号：US20140079666A1

  公开（公告）日：2014-03-20

  In one aspect, the invention relates to novel, broad-spectrum anti-viral, pyrimidinone compounds, methods of use, compositions and kits useful in treating and/or preventing influenza. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
• US9328075B2
  申请人：——

  公开号：US9328075B2

  公开（公告）日：2016-05-03