α,4'-dibromo-chalcone | 50603-95-7

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• 英文名称: α,4'-dibromo-chalcone
• 英文别名: 2-Brom-2-p-toluoyl-1-phenyl-ethylen；α,4'-Dibrom-chalkon；4.ω-Dibrom-ω-benzyliden-acetophenon
• CAS: 50603-95-7
• 化学式: C₁₅H₁₀Br₂O
• 分子量: 366.052
• InChiKey: ITGGXILGZVHQJE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.07
• 重原子数：
  18.0
• 可旋转键数：
  3.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  17.07
• 氢给体数：
  0.0
• 氢受体数：
  1.0

反应信息

• 作为反应物：
  描述：

  α,4'-dibromo-chalcone 、 sodium methylate 生成 1-(4-bromo-phenyl)-3,3-dimethoxy-3-phenyl-propan-1-one
  参考文献：
  名称：

  Weygand, Justus Liebigs Annalen der Chemie, 1927, vol. 459, p. 112

  摘要：

  DOI：

文献信息

• Chiral N,N′-dioxide-Sc(NTf₂)₃ complex-catalyzed asymmetric bromoamination of chalones with N-bromosuccinimide as both bromine and amide source
  作者：Zhengmeng Wang、Lili Lin、Pengfei Zhou、Xiaohua Liu、Xiaoming Feng

  DOI：10.1039/c7cc00470b

  日期：——

  A chiral N,N[prime or minute]-dioxide-Sc(NTf2)3 complex catalytic system has been developed to catalyze the asymmetric bromoamination reaction of chalones with N-bromosuccinimide.

  已经开发出手性的N，N [原始或分钟]-二氧化物-Sc（NTf 2）3络合物催化体系，以催化Chalones与N-溴代琥珀酰亚胺的不对称溴化反应。
• Synthesis of Polysubstituted 2-Aminoimidazoles via Alkene-Diamination of Guanidine with Conjugated α-Bromoalkenones
  作者：Sankar K. Guchhait、Neha Hura、Archana P. Shah

  DOI：10.1021/acs.joc.6b03021

  日期：2017.3.3

  A step-economical access to polysubstituted aminoimidazoles has been accomplished via alkene vicinal C–N bonds formation of 2-bromo-2-alkenones with guanidine avoiding its NH-protection/derivatization prerequisite for electronic modulation. The approach has excellent substrate scope, is amenable to diverse guanidine-containing substrates, and introduces distinctive substitutions/functionalities into

  通过2-邻位-2-烯酮与胍的烯烃邻位C-N键与胍的形成，避免了其电子保护的NH-保护/衍生化步骤，已实现了分步经济地获得多取代的氨基咪唑。该方法具有优异的底物范围，适用于各种含胍的底物，并且在氨基咪唑核心中引入了独特的取代/功能。它也适用于稠合咪唑的制备。该反应涉及氮杂-迈克尔加成的串联通路，S Ñ通过光谱研究和对照实验2，以及独特的氧化还原中性过程中，由于明显的。
• THE ACTION OF BASES ON ALPHA,BETA-DIBROMO KETONES AND RELATED SUBSTANCES
  作者：E. P. Kohler、C. R. Addinall

  DOI：10.1021/ja01372a048

  日期：1930.9
• Stereoselective cyclopropanation of α-bromochalcone with diethyl malonate promoted by K2CO3
  作者：Yongxian Sun、Gaosheng Yang、Yue Shen、Zan Hua、Zhuo Chai

  DOI：10.1016/j.tet.2013.02.011

  日期：2013.4

  A new Michael-initiated cyclopropanation reaction using alpha-bromochalcones as Michael acceptor was developed. Compared to previous works using arylidenemalonates as Michael acceptor, this novel protocol could improve the synthesis of trans-isomers of diethyl 2-benzoyl-3-phenyl-cyclopropane-1,1-dicarboxylates. More importantly, this method also provided the first access to the cis-isomers of these densely substituted cyclopropanes with the Michael-initiated ring closure (MIRC) strategy, albeit with a poor diastereoselectivity. (C) 2013 Published by Elsevier Ltd.
• Harode, Raju; Sharma, Journal of the Indian Chemical Society, 2002, vol. 79, # 2, p. 190 - 190
  作者：Harode, Raju、Sharma

  DOI：——

  日期：——