4-氯-3-甲基-1-苯基丁烷-1-酮 | 105905-49-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 4-氯-3-甲基-1-苯基丁烷-1-酮
• 英文名称: 4-chloro-3-methyl-1-phenylbutan-1-one
• 英文别名: γ-Chlor-β-methyl-butyrophenon
• CAS: 105905-49-5
• 化学式: C₁₁H₁₃ClO
• 分子量: 196.677
• InChiKey: GCPIHQONHVQYFA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  2-methyl-4-phenylbut-3-yn-1-ol 在 palladium dichloride 作用下， 以 二氯甲烷 为溶剂， 反应 2.0h， 以90%的产率得到4-氯-3-甲基-1-苯基丁烷-1-酮
  参考文献：
  名称：

  Csp–Csp 3通过铁（III）促进的未活化烯烃的加氢烷基化反应形成键

  摘要：

  已开发出铁（III）促进未活化烯烃向Csp–Csp 3键形成的加氢烷基化反应。在这种化学选择性方案中，各种烯烃，包括单，二和三取代的烯烃，都可以平稳地转化为结构多样化的炔烃。此外，还没有对可扩展性进行说明，并且对产品进行了进一步多样化的转换以证明其综合实用性。

  DOI：

  10.1021/acs.orglett.7b00499

文献信息

• COMPOSITIONS AND METHODS FOR TYPE III POLYKETIDE PRODUCTION IN OLEAGINOUS YEAST SPECIES
  申请人：Board of Regents, The University of Texas System

  公开号：EP3430124A1

  公开（公告）日：2019-01-23
• MICROBIAL PRODUCTION OF CHEMICAL PRODUCTS AND RELATED COMPOSITIONS, METHODS AND SYSTEMS
  申请人：Lynch Michael D.

  公开号：US20140330032A1

  公开（公告）日：2014-11-06

  Metabolically engineered microorganism strains are disclosed, such as bacterial strains, in which there is an increased utilization of malonyl-CoA for production of a chemical product. Such chemical products include polyketides, 3-hydroxypropionic acid, and various other chemical products described herein. Methods of production also may be applied to further downstream products, such as consumer products. In various embodiments, modifications to a microorganism and/or culture system divert, at least transiently, usage of malonyl-coA from the fatty acid biosynthesis pathway and thereby provides for usage of the malonyl-coA for a chemical product other than a fatty acid. In various embodiments, the fatty acid biosynthesis pathway is modulated to produce specific fatty acids or combinations of fatty acids.
• US4101585A
  申请人：——

  公开号：US4101585A

  公开（公告）日：1978-07-18
• [EN] COMPOSITIONS AND METHODS FOR TYPE III POLYKETIDE PRODUCTION IN OLEAGINOUS YEAST SPECIES<br/>[FR] COMPOSITIONS ET PROCÉDÉS POUR LA PRODUCTION DE POLYCÉTIDES DE TYPE III DANS DES ESPÈCES DE LEVURES OLÉAGINEUSES
  申请人：UNIV TEXAS

  公开号：WO2017160801A1

  公开（公告）日：2017-09-21

  This invention relates to compositions and methods for the production of Type III polyketides using genetically modified oleaginous yeast strains, for example, Yarrowia lipolytica.
• Csp–Csp³ Bond Formation via Iron(III)-Promoted Hydroalkynylation of Unactivated Alkenes
  作者：Yangyong Shen、Bo Huang、Jing Zheng、Chen Lin、Yu Liu、Sunliang Cui

  DOI：10.1021/acs.orglett.7b00499

  日期：2017.4.7

  An iron(III)-promoted hydroalkynylation of unactivated alkenes toward Csp–Csp3 bond formation has been developed. Various alkenes, including mono-, di-, and trisubstituted alkenes, could all smoothly convert to structural diversified alkynes in this chemoselective protocol. Additionally, the scalability was unraveled and the further divergent transformations of products were conducted to demonstrate

  已开发出铁（III）促进未活化烯烃向Csp–Csp 3键形成的加氢烷基化反应。在这种化学选择性方案中，各种烯烃，包括单，二和三取代的烯烃，都可以平稳地转化为结构多样化的炔烃。此外，还没有对可扩展性进行说明，并且对产品进行了进一步多样化的转换以证明其综合实用性。