2',3'-Dideoxyadenosine-5'-Phosphorothioate | 1266500-93-9

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘌呤核苷
• 英文名称: 2',3'-Dideoxyadenosine-5'-Phosphorothioate
• 英文别名: 9-[(2R,5S)-5-(dihydroxyphosphinothioyloxymethyl)oxolan-2-yl]purin-6-amine
• CAS: 1266500-93-9
• 化学式: C₁₀H₁₄N₅O₄PS
• 分子量: 331.292
• InChiKey: XHZQMJHQJKTFCZ-NKWVEPMBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  161
• 氢给体数：
  3
• 氢受体数：
  9

文献信息

• [EN] CYCLIC DINUCLEOTIDES AS ANTICANCER AGENTS<br/>[FR] DINUCLÉOTIDES CYCLIQUES UTILISÉS EN TANT QU'AGENTS ANTICANCÉREUX
  申请人：BRISTOL MYERS SQUIBB CO

  公开号：WO2019046496A1

  公开（公告）日：2019-03-07

  The present invention is directed to compounds of the formula (I) wherein all substituents are defined herein, as well as pharmaceutically acceptable compositions comprising compounds of the invention and methods of using said compositions in the treatment of various disorders.

  本发明涉及式(I)的化合物，其中所有取代基在此定义，以及包括本发明化合物的药学上可接受的组合物，以及使用这些组合物治疗各种疾病的方法。
• [EN] BICYCLIC PEPTIDE LIGAND STING CONJUGATES AND USES THEREOF<br/>[FR] CONJUGUÉS PEPTIDE-LIGAND BICYCLIQUE ET LEURS UTILISATIONS
  申请人：BICYCLETX LTD

  公开号：WO2020165600A1

  公开（公告）日：2020-08-20

  The present invention provides compounds, compositions thereof, and methods of using the same.

  本发明提供了化合物、其组合物以及使用方法。
• CYCLIC DINUCLEOTIDE COMPOUNDS
  申请人：BOEHRINGER INGELHEIM INTERNATIONAL GMBH

  公开号：US20180092937A1

  公开（公告）日：2018-04-05

  The present invention relates to compounds of general formula I, wherein the groups R 1 , R 2 and R 3 are defined as in claim 1 , which have valuable pharmacological properties, particularly are modulators of STING.

  本发明涉及一般式I的化合物，其中R1、R2和R3基团的定义如权利要求书中所述，具有有价值的药理学特性，特别是STING的调节剂。
• [EN] NUCLEOSIDE-THIODIPHOSPHATE-HEPTOSE COMPOUNDS FOR TREATING CONDITIONS ASSOCIATED WITH ALPK1 ACTIVITY<br/>[FR] COMPOSÉS NUCLÉOSIDE-THIODIPHOSPHATE-HEPTOSE POUR TRAITER DES AFFECTIONS ASSOCIÉES À L'ACTIVITÉ DE L'ALPK1
  申请人：PYROTECH BEIJING BIOTECHNOLOGY CO LTD

  公开号：WO2022127914A1

  公开（公告）日：2022-06-23

  The invention concerns compounds of formula (I) which modulate, especially agonize alpha kinase 1 (ALPK1) and are useful for treating a condition, disease or disorder in which a decrease or increase in ALPK1 activity contributes to the pathology or symptoms or progression of the condition, disease or disorder such as cancer, immune or inflammatory related diseases.

  本发明涉及式(I)的化合物，该化合物调节，特别是激活α激酶1(ALPK1)，并且适用于治疗某种疾病、病症或障碍，其中ALPK1活性的降低或增加会导致该疾病、病症或障碍的病理学、症状或进展，例如癌症、免疫或炎症相关疾病。
• Post-synthesis labeling of nucleic acids, assays using nucleic acids that are labeled post-synthetically, single nucleotide polymorphism detection, and associated compounds and microarrays
  申请人：MOTOROLA, INC.

  公开号：US20030119005A1

  公开（公告）日：2003-06-26

  An assay is provided for nucleic acids that can be post-synthetically labeled, wherein modified nucleoside triphosphates are used that are more efficiently and specifically incorporated during nucleic acid synthesis than labeled nucleoside triphosphates. In a preferred embodiment, nucleoside &agr;-thiotriphosphates are utilized. Maleimide or iodoacetamide conjugating moieties can be attached post-synthetically. The conjugating moieties may include a reporter group. Also disclosed are new methods for detecting single nucleotide polymorphism.

  提供了一种可在合成后标记核酸的检测方法，其中使用了修饰的核苷三磷酸酯，这种核苷三磷酸酯在核酸合成过程中比标记的核苷三磷酸酯更有效、更特异。在一个优选的实施方案中，使用的是核苷三磷酸酯。马来酰亚胺或碘乙酰胺共轭分子可在合成后连接。共轭分子可包括报告基团。还公开了检测单核苷酸多态性的新方法。