7-(benzo[d][1,3]dioxol-5-yl)-10-(1,3-dithiolan-2-ylidene)-3,3-dimethylspiro[5.5]undecane-1,5,9-trione | 1142319-81-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并间二氧杂环戊烯类
• 英文名称: 7-(benzo[d][1,3]dioxol-5-yl)-10-(1,3-dithiolan-2-ylidene)-3,3-dimethylspiro[5.5]undecane-1,5,9-trione
• 英文别名: 11-(1,3-Benzodioxol-5-yl)-8-(1,3-dithiolan-2-ylidene)-3,3-dimethylspiro[5.5]undecane-1,5,9-trione
• CAS: 1142319-81-0
• 化学式: C₂₃H₂₄O₅S₂
• 分子量: 444.573
• InChiKey: QSYVNAUOKOWRQM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  30
• 可旋转键数：
  1
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.52
• 拓扑面积：
  120
• 氢给体数：
  0
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  聚合甲醛 、 4-(benzo[d][1,3]dioxol-5-yl)-1-(1,3-dithiolan-2-ylidene)but-3-en-2-one 、 5,5-二甲基-1,3-环己二酮 在 溶剂黄146 作用下， 以 四氢呋喃 、 水 为溶剂， 反应 0.75h， 以71%的产率得到7-(benzo[d][1,3]dioxol-5-yl)-10-(1,3-dithiolan-2-ylidene)-3,3-dimethylspiro[5.5]undecane-1,5,9-trione
  参考文献：
  名称：

  α-Alkenoyl Ketene S,S-Acetal-Based Multicomponent Reaction: An Efficient Approach for the Selective Construction of Polyfunctionalized Cyclohexanones

  摘要：

  A versatile multicomponent reaction based on the new four-carbon synthons alpha-alkenoyl ketene S,S-acetals 1 has been developed. This three-component reaction of readily available alpha-alkenoyl ketene S,S-acetals 1 with aldehydes 2 and active methylene compounds 3 proceeds smoothly in acidic medium (glacial acetic acid in tetrahydrofuran) to give various polyfunctionalized cyclohexanones 4, 5, and 6 in a highly regio- and diastereoselective manner with good to excellent yields. The reaction can tolerate a broad range of substituents in the three components involved and is proposed to proceed via a tandem Knoevenagel-intermolecular Michael-intramolecular Michael sequence. As an extension of the synthetic application of polyfunctionalized cyclohexanones obtained, unsymmetrical biaryls 7 were synthesized in almost quantitative yields by simple transformations of the corresponding cycloadducts 6.

  DOI：

  10.1021/jo900217g

文献信息

• α-Alkenoyl Ketene <i>S</i>,<i>S</i>-Acetal-Based Multicomponent Reaction: An Efficient Approach for the Selective Construction of Polyfunctionalized Cyclohexanones
  作者：Yuhui Ma、Mang Wang、Dan Li、Bahargul Bekturhun、Jun Liu、Qun Liu

  DOI：10.1021/jo900217g

  日期：2009.4.17

  A versatile multicomponent reaction based on the new four-carbon synthons alpha-alkenoyl ketene S,S-acetals 1 has been developed. This three-component reaction of readily available alpha-alkenoyl ketene S,S-acetals 1 with aldehydes 2 and active methylene compounds 3 proceeds smoothly in acidic medium (glacial acetic acid in tetrahydrofuran) to give various polyfunctionalized cyclohexanones 4, 5, and 6 in a highly regio- and diastereoselective manner with good to excellent yields. The reaction can tolerate a broad range of substituents in the three components involved and is proposed to proceed via a tandem Knoevenagel-intermolecular Michael-intramolecular Michael sequence. As an extension of the synthetic application of polyfunctionalized cyclohexanones obtained, unsymmetrical biaryls 7 were synthesized in almost quantitative yields by simple transformations of the corresponding cycloadducts 6.