1-(1-碘乙烯基)-4-甲氧基苯 | 29443-55-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 中文名称: 1-(1-碘乙烯基)-4-甲氧基苯
• 英文名称: 1-(1-iodoethenyl)-4-methoxybenzene
• 英文别名: 1-(1-iodovinyl)-4-methoxybenzene；p-Methoxy-α-Jodostyrol
• CAS: 29443-55-8
• 化学式: C₉H₉IO
• 分子量: 260.074
• InChiKey: UOLJCPMNNFFQSN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  1-(1-碘乙烯基)-4-甲氧基苯 在 bis-triphenylphosphine-palladium(II) chloride 、 磷块岩 、 5% Rh/C 、 phosphite dehydrogenase 、 recombinant Thermobifida fusca phenylacetone monooxygenase M₄₄₆G mutant 、 potassium phenolate 、 氢气 、 双氧水 、 氧气 、 三苯基膦 、 还原型辅酶II(NADPH)四钠盐 、 sodium hydroxide 作用下， 以 二甲基亚砜 、 甲苯 为溶剂， 反应 10.0h， 生成 (S)-(-)-对甲氧基苯乙醇
  参考文献：
  名称：

  Exploiting the enantioselectivity of Baeyer-Villiger monooxygenases via boron oxidation

  摘要：

  The enantioselective carbon-boron bond oxidation of several chiral boron-containing compounds by Baeyer-Villiger monooxygenases was evaluated. PAMO and M446G PAMO conveniently oxidized 1-phenylethyl boronate into the corresponding 1-(phenyl)ethanol (ee = 82-91%). Cyclopropyl boronic esters were also oxidized but with no enantioselectivity. beta-Boryl carboxylic esters were not oxidized by any BVMOs. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2012.05.004
• 作为产物：
  描述：

  4-乙炔基苯甲醚 在 cerium(III) chloride heptahydrate 、 sodium iodide 作用下， 以 乙腈 为溶剂， 生成 1-(1-碘乙烯基)-4-甲氧基苯
  参考文献：
  名称：

  光催化氧化自由基加成合成不对称 1,4-二羰基化合物

  摘要：

  在此，我们报道了一种用于合成不对称 1,4-二羰基化合物的光催化氧化自由基加成反应。该反应利用脱硫过程产生亲电自由基，该自由基与 α-卤代烯烃相加并进一步氧化以产生 1,4-二羰基化合物。这种温和且高效的方法为已知策略提供了一种有价值的替代方法。

  DOI：

  10.1021/acs.orglett.1c02208

文献信息

• [EN] THERAPEUTIC COMPOUNDS AND USES THEREOF<br/>[FR] COMPOSÉS THÉRAPEUTIQUES ET LEURS UTILISATIONS
  申请人：GENENTECH INC

  公开号：WO2016055028A1

  公开（公告）日：2016-04-14

  The present invention relates to compounds of formula (I): and to salts thereof, wherein A has any of the values defined in the specification, and compositions and uses thereof. The compounds are useful as inhibitors of CBP and/or EP300. Also included are pharmaceutical compositions comprising a compound of formula (I) or a pharmaceutically acceptable salt thereof, and methods of using such compounds and salts in the treatment of various CBP and/or EP300-mediated disorders.

  本发明涉及式(I)的化合物及其盐，其中A具有规范中定义的任何值，以及其组合物和用途。这些化合物可用作CBP和/或EP300的抑制剂。还包括包含式(I)的化合物或其药学上可接受的盐的药物组合物，以及在治疗各种CBP和/或EP300介导的疾病中使用这些化合物和盐的方法。
• Generation and Rearrangement of <i>N</i> , <i>O</i> ‐Dialkenylhydroxylamines for the Synthesis of 2‐Aminotetrahydrofurans
  作者：Jongwoo Son、Tyler W. Reidl、Ki Hwan Kim、Donald J. Wink、Laura L. Anderson

  DOI：10.1002/anie.201800908

  日期：2018.5.28

  provide modular access to these novel rearrangement precursors. The scope of this de novo synthesis of simple nucleoside analogues has been explored to reveal trends in diastereoselectivity and reactivity. In addition, a base‐promoted ring‐opening and Mannich reaction has been discovered to covert 2‐aminotetrahydrofurans to cyclopentyl β‐aminoacid derivatives or cyclopentenones.

  由N，O-二烯基羟胺开发了一条新的非对映选择性路线来生成2-氨基四氢呋喃。这些中间体经历了自发的CC键形成[3,3]-σ重排，随后是CO键形成的环化。N -Boc-羟胺与烯基碘化物的铜催化N-烯基化反应，以及碱促进的N的加成反应缺电子的烯丙基的羟基烯胺为这些新颖的重排前体提供了模块化的通道。已经探索了从头合成简单核苷类似物的范围，以揭示非对映选择性和反应性的趋势。此外，还发现碱促进的开环和曼尼希反应将2-氨基四氢呋喃转化为环戊基β-氨基酸衍生物或环戊烯酮。
• OPTICALLY ACTIVE CROSS-LINKED POLYMER
  申请人：PreSens Precision Sensing GmbH

  公开号：EP3168616A1

  公开（公告）日：2017-05-17

  The present invention relates to a cross-linked polymer comprising at least one detector group, at least one ionic group and optionally at least one hydrophilic group, as well as a method for its preparation and its use as a sensor and in an analyte sensor assembly.

  本发明涉及一种交联聚合物，该聚合物包含至少一个检测基团、至少一个离子基团和可选的至少一个亲水基团，本发明还涉及一种制备方法及其作为传感器和分析物传感器组件的用途。
• Pross,A.; Sternhell,S., Australian Journal of Chemistry, 1970, vol. 23, p. 989 - 1003
  作者：Pross,A.、Sternhell,S.

  DOI：——

  日期：——
• Highly regioselective hydroiodination of terminal alkynes and silylalkynes with iodine and phosphorus reagents leading to internal iodoalkenes
  作者：Shin-ichi Kawaguchi、Haruna Masuno、Motohiro Sonoda、Akihiro Nomoto、Akiya Ogawa

  DOI：10.1016/j.tet.2012.08.096

  日期：2012.11

  Markovnikov-type hydroiodination of terminal alkynes with iodine and Ph2P(O)H took place selectively to afford the corresponding internal iodoalkenes in good yields. Combination of (PhO)(2)P(O)H and Ph2P(O)OH instead of Ph2P(O)H also provided internal iodoalkenes in excellent yields. This hydroiodination is advantageous in terms of mild conditions, convenient operation, and tolerance to various functional groups. In addition, direct synthesis of internal iodoalkenes from silylalkynes was also achieved by using a mixed system of iodine and phosphorus reagents. (c) 2012 Elsevier Ltd. All rights reserved.