5-chloromethyl-2-(5-methyl-2-phenyl-4-oxazolylmethoxy)pyridine | 339269-11-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 5-chloromethyl-2-(5-methyl-2-phenyl-4-oxazolylmethoxy)pyridine
• 英文别名: 5-chloromethyl-2-(5-methyl-2-phenyl-4-oxazolylmethoxy)pyridyne；5-Chloromethyl-2-(5-methyl-2-phenyl-4-oxazolyl)methoxypyridine；4-[[5-(chloromethyl)pyridin-2-yl]oxymethyl]-5-methyl-2-phenyl-1,3-oxazole
• CAS: 339269-11-3
• 化学式: C₁₇H₁₅ClN₂O₂
• 分子量: 314.771
• InChiKey: LKDAQODQXCDUSB-UHFFFAOYSA-N

物化性质

• 沸点：
  488.2±55.0 °C(Predicted)
• 密度：
  1.245±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  22
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  48.2
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  5-chloromethyl-2-(5-methyl-2-phenyl-4-oxazolylmethoxy)pyridine 、 5-苯基-1H-吡唑-4-羧酸乙酯 在 sodium hydride 作用下， 以 DMF (N,N-dimethyl-formamide) 为溶剂， 反应 8.0h， 以57%的产率得到ethyl 1-[6-(5-methyl-2-phenyl-4-oxazolylmethoxy)-3-pyridylmethyl]-3-phenyl-1H-pyrazole-4-carboxylate
  参考文献：
  名称：

  5-MEMBERED N-HETEROCYCLIC COMPOUNDS WITH HYPOGLYCEMIC AND HYPOLIPIDEMIC ACTIVITY

  摘要：

  公开号：

  EP1228067B1
• 作为产物：
  描述：

  2-(5-methyl-2-phenyl-4-oxazolylmethoxy)pyridine-5-methanol 在 氯化亚砜 作用下， 以 甲苯 为溶剂， 反应 1.0h， 以90%的产率得到5-chloromethyl-2-(5-methyl-2-phenyl-4-oxazolylmethoxy)pyridine
  参考文献：
  名称：

  EP1394154

  摘要：

  公开号：

文献信息

• PROCESS FOR PRODUCTION OF PYRAZOLE COMPOUNDS
  申请人：Takeda Chemical Industries, Ltd.

  公开号：EP1445254A1

  公开（公告）日：2004-08-11

  As a method capable of conveniently producing a pyrazole compound in a high yield, which is useful as a synthetic intermediate for a pharmaceutical agent such as a therapeutic agent for diabetes and the like, a production method of a compound represented by the formula (I) wherein n is an integer of 1 to 4 and R1 is a hydrocarbon group optionally having substituents, or a salt thereof, is provided, which includes reacting a compound represented by the formula (II) wherein Q is a hydroxy group optionally having substituents or an amino group optionally having substituents, R is a hydrocarbon group optionally having substituents and other symbols are as defined above, or a salt thereof, with hydrazine or a salt thereof.

  提供一种制备嘧唑烷化合物的方法，该方法能够方便地高产得到嘧唑烷化合物，该化合物可用作制药中间体，例如治疗糖尿病等治疗剂的合成中间体。该制备方法包括将式（II）所表示的化合物与肼或其盐反应，其中n为1至4的整数，R1为具有取代基的烃基或其盐。式（II）中Q为具有取代基的羟基或氨基，R为具有取代基的烃基，其他符号如上所定义。
• Five-membered heterocyclic alkanoic acid derivative
  申请人：——

  公开号：US20040063775A1

  公开（公告）日：2004-04-01

  The present invention relates to a compound represented by the formula 1 wherein R 1 is an optionally substituted 5-membered heterocyclic group; X is a bond etc.; Q is a divalent hydrocarbon group having 1 to 20 carbon atoms; Y is a bond etc.; ring A is an aromatic ring optionally further having 1 to 3 substituents; Z is —(CH 2 ) n —Z 1 — (n is an integer of 0 to 8 and Z 1 is a bond etc.) and the like; ring B is a 5-membered heterocycle optionally further having 1 to 3 substituents; W is a divalent saturated hydrocarbon group having 1 to 20 carbon atoms; R 2 is —OH etc., or a salt thereof. A pharmaceutical composition containing this compound is useful as a prophylactic or therapeutic agent of diseases such as diabetes mellitus and the like.

  本发明涉及一种由式1表示的化合物，其中R1是可选择取代的5元杂环基团; X是一个键等; Q是具有1到20个碳原子的双价碳氢基团; Y是一个键等; 环A是一个芳香环，可选择进一步具有1到3个取代基; Z是—(CH2)n—Z1—(n为0到8的整数，Z1是一个键等)等; 环B是一个可选择进一步具有1到3个取代基的5元杂环; W是具有1到20个碳原子的双价饱和碳氢基团; R2是—OH等，或其盐。包含该化合物的制药组合物可用作糖尿病等疾病的预防或治疗剂。
• Process for production of pyrazole compounds
  申请人：Tawada Hiroyuki

  公开号：US20050014813A1

  公开（公告）日：2005-01-20

  As a method capable of conveniently producing a pyrazole compound in a high yield, which is useful as a synthetic intermediate for a pharmaceutical agent such as a therapeutic agent for diabetes and the like, a production method of a compound represented by the formula (I) wherein n is an integer of 1 to 4 and R 1 is a. hydrocarbon group optionally having substituents, or a salt thereof, is provided, which includes reacting a compound represented by the formula, (II) wherein Q is a hydroxy group optionally having substituents or an amino group optionally having substituents, R is a hydrocarbon group optionally having substituents and other symbols are as defined above, or a salt thereof, with hydrazine or a salt thereof.

  作为一种能够方便地高产生产吡唑烷化合物的方法，该方法对于制备药物中间体如治疗糖尿病等治疗剂非常有用，提供了一种化合物的生产方法，该化合物由式（I）所表示，其中n是1至4的整数，R1是一个烃基，可选择地具有取代基，或其盐，包括将由式（II）所表示的化合物与肼或其盐反应，其中Q是一个羟基，可选择地具有取代基，或一个氨基，可选择地具有取代基，R是一个烃基，可选择地具有取代基，其他符号如上所定义。
• Alkanoic acid derivatives process for their production and use thereof
  申请人：——

  公开号：US20040058965A1

  公开（公告）日：2004-03-25

  An alkanoic acid derivative useful as a prophylactic or therapeutic agent of diabetes mellitus, hyperlipidemia, impaired glucose tolerance and the like can be provided by a compound represented by the formula 1 wherein R 1 is an optionally substituted 5-membered aromatic heterocyclic group; X is a bond and the like; Q is a divalent hydrocarbon group having 1 to 20 carbon atoms; Y is a bond and the like, ring A is an aromatic ring optionally further having 1 to 3 substituents; Z is —(CH 2 ) n —Z 1 — (n is an integer of 1 to 8 and Z 1 is an oxygen atom and the like) and the like; ring B is a pyridine ring optionally further having 1 to 3 substituents, and the like; U is a bond and the like; W is a divalent hydrocarbon group having 1 to 20 carbon atoms; and R 3 is —OH and the like, provided that, when ring B is a benzene ring optionally further having 1 to 3 substituents, U should be a bond, or a salt thereof.

  一种可以用作糖尿病、高脂血症、糖耐量受损等预防或治疗剂的脂肪酸衍生物可以由以下式1所表示的化合物提供，其中R1是可选取代的5-成员芳香杂环基；X是键等；Q是具有1到20个碳原子的二价碳氢基团；Y是键等；环A是一种芳香环，可选择进一步具有1到3个取代基；Z是—（CH2）n—Z1—（n是1到8的整数，Z1是氧原子等）等；环B是吡啶环，可选择进一步具有1到3个取代基等；U是键等；W是具有1到20个碳原子的二价碳氢基团；R3是—OH等；但是，当环B是苯环，可选择进一步具有1到3个取代基时，U应为键，或其盐。
• 5-membered n-heterocyclic compounds with hypoglycemic and hypolipidemic activity
  申请人：Takeda Pharmaceutical Company Limited

  公开号：US07179823B1

  公开（公告）日：2007-02-20

  A compound of formula (I) F wherein R1 represents a hydrocarbon group which may be substituted or a heterocyclic group which may be substituted; x represents a bond, an oxygen atom, a sulfur atom, or a group of the formula: —CO—, —CS—, —CR4(OR5)— or —NR6— wherein each of R4 and R6 represents a hydrogen atom or a hydrocarbon group which may be stubstituted, R5 represents a hydrogen atom or a protective group for a hydroxyl group; m represents an integer of 0 to 3; Y represents an oxygen atom, a sulfur atom, or a group of the formula: —SO—, —SO2—, —NR7—, —CONR7— or —NR7CO— wherein R7 represents a hydrogen atom or a hydrocarbon group which may be substituted; ring A represents an aromatic ring which may further have 1 to 3 substituents; n represents an integer of 1 to 8; ring B represents a nitrogen-containing 5-membered hetero ring which may further be substituted by an alkyl group.

  化合物的式子为（I）F，其中R1代表一个可以被取代的碳氢基团或杂环基团；x代表一个键、一个氧原子、一个硫原子或者一个式子为：—CO—、—CS—、—CR4(OR5)—或—NR6—的基团，其中R4和R6分别代表一个氢原子或者一个可以被取代的碳氢基团，R5代表一个氢原子或者一个羟基的保护基团；m代表一个0到3的整数；Y代表一个氧原子、一个硫原子或者一个式子为：—SO—、—SO2—、—NR7—、—CONR7—或—NR7CO—的基团，其中R7代表一个氢原子或者一个可以被取代的碳氢基团；环A代表一个芳香环，可以有1到3个取代基；n代表一个1到8的整数；环B代表一个含氮的5元杂环，可以有一个烷基的取代基。