2,6-di-O-acetyl-3,4-di-O-benzoyl-α-D-galactopyranosyl trichloroacetimidate | 663622-36-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2,6-di-O-acetyl-3,4-di-O-benzoyl-α-D-galactopyranosyl trichloroacetimidate
• 英文别名: Bz(-3)[Bz(-4)]Gal2Ac6Ac(a)-O-C(NH)CCl3；[(2R,3S,4S,5R,6R)-5-acetyloxy-2-(acetyloxymethyl)-4-benzoyloxy-6-(2,2,2-trichloroethanimidoyl)oxyoxan-3-yl] benzoate
• CAS: 663622-36-4
• 化学式: C₂₆H₂₄Cl₃NO₁₀
• 分子量: 616.836
• InChiKey: KAIYEBQWVQHIMV-IZBDVAQHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.9
• 重原子数：
  40
• 可旋转键数：
  13
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  148
• 氢给体数：
  1
• 氢受体数：
  11

反应信息

• 作为反应物：
  描述：

  2,6-di-O-acetyl-3,4-di-O-benzoyl-α-D-galactopyranosyl trichloroacetimidate 在 三氟甲磺酸三甲基硅酯 、 乙酰氯 作用下， 以 甲醇 、 二氯甲烷 为溶剂， 反应 51.0h， 生成 4-methoxyphenyl 2,3,4,6-tetra-O-benzoyl-β-D-galactopyranosyl-(1->6)-2-O-acetyl-3,4-di-O-benzoyl-β-D-galactopyranoside
  参考文献：
  名称：

  Domain decomposition methods of dual-primal FETI type for edge element approximations in three dimensions

  摘要：

  We consider domain decomposition algorithms of FETI type for edge element approximations in three dimensions. We first show that a strong coupling exists between tangential degrees of freedom associated to the subdomain edges and faces. We then propose a dual-primal FETI algorithm that relies on a change of basis and on a suitable choice of a coarse space. We give a logarithmic bound for the condition number of the resulting preconditioned operator. Numerical results confirm this bound and the necessity of performing a change of basis. (C) 2004 Academie des sciences. Published by Elsevier SAS. All fights reserved.

  DOI：

  10.1016/j.crma.2004.09.021
• 作为产物：
  描述：

  (2R,3S,4S,5R)-5,6-diacetoxy-2-(acetoxymethyl)tetrahydro-2H-pyran-3,4-diyl dibenzoate 在 1,8-二氮杂双环[5.4.0]十一碳-7-烯 、 苄胺 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 反应 29.0h， 生成 2,6-di-O-acetyl-3,4-di-O-benzoyl-α-D-galactopyranosyl trichloroacetimidate
  参考文献：
  名称：

  An Efficient Method for the Synthesis of 2,6-Branched Galacto-Oligo­saccharides and Its Applications to the Synthesis of Three Tetrasaccharides and a Hexasaccharide Related to the Arabinogalactans (AGs)

  摘要：

  通过使用6-O-Ac-2,3,4-三-O-Bz-α-d-半乳糖吡喃糖苷三氯乙酰亚胺、2,6-二-O-Ac-3,4-二-O-Bz-α-d-半乳糖吡喃糖苷三氯乙酰亚胺和2-O-Ac-3,4,6-三-O-Bz-α-d-半乳糖吡喃糖苷三氯乙酰亚胺作为合成砌块，开发了一种高效合成2,6-支化半乳寡糖的方法。利用这种方法，可以方便地制备与植物来源的AGs相关的三种四糖和一种六糖。

  DOI：

  10.1055/s-2003-42109

文献信息

• Concise syntheses of arabinogalactans with β-(1→6)-linked galactopyranose backbones and α-(1→3)- and α-(1→2)-linked arabinofuranose side chains
  作者：Aixiao Li、Fanzuo Kong

  DOI：10.1016/j.bmc.2004.10.035

  日期：2005.2

  4-Methoxyphenyl glycosides of 2,3"-bis-alpha-L-arabinofuranosyl branched beta-D-(1-6)-linked galactopyranosyl tetraose (16), 3',2""-bis-alpha-L-arabinofuranosyl branched beta-D-(1-->6)-linked Plactopyranosyl hexaose (27), and a twentyose (42) consisting of beta- (1-->6)-linked D-galactopyranosyl pen tadecaoligosaccha ride backbone with alpha-L-arabinofuranosyl side chains alternatively attached at C-2 and C-3 of the middle galactose residue of each consecutive beta-(1-->6)-linked galactotriose unit of the backbone. were synthesized with isopropyl 3-O-allyl-2.4-di-O-benzoyl-1-thio-beta-D-galactopyranoside (6). 2.3.4.6-tetra-O-benzoyl-alpha-D-galactopyranosyl trichloroacetimidate (7), 2,.3,5-tri-O-benzoyl-alpha-L-arabinofuranosyl trichloroacetimidate (12), 6-O-acetyl-2,3,4-tn-O-benzoyl-alpha-D-galactopyranosyl trichloroacetimidate (17), 4-methoxyphenyl 2,3,4-tri-O-benzo-beta-D-galactopyranoside (19), and 2,6-di-O-acetyl-3,4-di-O-benzoyl-alpha-D-galactopyranosyl trichloroacetimidate (28) as the key synthons. Condensation of 6 with 7 gave the disaccharide donor 8, and subsequent condensation of 8 with 4-methoxyphenyl 2.3.4-tri-O-benzoyl-beta-D-galactopyranosyl-(1-->6)-2-O-acetyl-3,4-di-O-benzoyl-beta-D-galactopyranoside (9) followed by selective deacetylation afforded the tetrasaccharide acceptor 11. Coupling of I I with 12 gave the pentasaccharide 13, its deallylation followed by coupling with 12. and debenzoylation Rave the hexasaccharide 16 with beta-(1-->6)-linked galactopyranose backbone and 2- and 3"-linked alpha-L-arabinofuranose side chains. The octasaccharide 27 was similarly synthesized, while the twentyoside 42 was synthesized with tetrasaccharides 33 or 24 as the donors and 23, 36, 38, and 40 as the acceptors by consecutive couplings followed by deacylation. (C) 2004 Elsevier Ltd. All rights reserved.