(2E,6E)-3-chloro-4,6-dihydroxy-2-methyl-5-(8-hydroxy-3',7'-dimethyl-2',6'-nonadienyl)acetophenone | 1374767-18-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (2E,6E)-3-chloro-4,6-dihydroxy-2-methyl-5-(8-hydroxy-3',7'-dimethyl-2',6'-nonadienyl)acetophenone
• 英文别名: 1-[5-chloro-2,4-dihydroxy-3-[(2E,6E)-8-hydroxy-3,7-dimethylnona-2,6-dienyl]-6-methylphenyl]ethanone
• CAS: 1374767-18-6
• 化学式: C₂₀H₂₇ClO₄
• 分子量: 366.885
• InChiKey: KRZZHEMGFXBHOD-FYDMFQIUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  25
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  77.8
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• DIHYDROOROTIC AND ACID DEHYDROGENASE INHIBITOR
  申请人：NAI INC.

  公开号：US20160296494A1

  公开（公告）日：2016-10-13

  The present invention provides a novel dihydroorotic acid dehydrogenase inhibitor which is applicable to various diseases. When used as an active ingredient, a compound represented by formula (I): (wherein X represents a halogen atom, R 1 represents a hydrogen atom, R 2 represents an alkyl group containing 1 to 7 carbon atoms, R 3 represents —CHO, and R 4 represents —CH 2 —CH═C(CH 3 )—R 0 (wherein R 0 represents an alkyl group containing 1 to 12 carbon atoms which may have a substituent on the terminal carbon and/or on a non-terminal carbon, etc.)), an optical isomer thereof or a pharmaceutically acceptable salt thereof has a high inhibitory effect on dihydroorotic acid dehydrogenase and can be used as an immunosuppressive agent, a therapeutic agent for rheumatism, an anticancer agent, a therapeutic agent for graft rejection, an antiviral agent, an anti- H. pylori agent, a therapeutic agent for diabetes or the like.
• US9737504B2
  申请人：——

  公开号：US9737504B2

  公开（公告）日：2017-08-22