tetrakis(5-mesyloxy-2-oxapentyl)methane | 438458-90-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磺酸及其衍生物
• 英文名称: tetrakis(5-mesyloxy-2-oxapentyl)methane
• 英文别名: 3-[3-(3-Methylsulfonyloxypropoxy)-2,2-bis(3-methylsulfonyloxypropoxymethyl)propoxy]propyl methanesulfonate
• CAS: 438458-90-3
• 化学式: C₂₁H₄₄O₁₆S₄
• 分子量: 680.835
• InChiKey: FRXFEFHCXFLRFT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.1
• 重原子数：
  41
• 可旋转键数：
  28
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  244
• 氢给体数：
  0
• 氢受体数：
  16

反应信息

• 作为反应物：
  描述：

  tetrakis(5-mesyloxy-2-oxapentyl)methane 在 10percent Pd/C sodium azide 、 氢气 作用下， 以 甲醇 、 N,N-二甲基甲酰胺 为溶剂， 反应 5.0h， 生成 tetrakis(5-amino-2-oxapentyl)methane
  参考文献：
  名称：

  Improved Synthesis of an Ethereal Tetraamine Core for Dendrimer Construction

  摘要：

  A new route to a pentaerythritol-based tetraamine is delineated and subsequently contrasted to a previous report. Access to the pure tetraamine is facilitated by the smooth reduction of its tetraazide precusor. Characterization includes the preparation of a 4:1 Zn-tetraphenylporphyrin/tetraamine complex.

  DOI：

  10.1021/jo025625p
• 作为产物：
  描述：

  四(氰基乙氧基甲基)甲烷 在 盐酸 、 dimethylsulfide borane complex 、 水 、 三乙胺 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 反应 4.0h， 生成 tetrakis(5-mesyloxy-2-oxapentyl)methane
  参考文献：
  名称：

  基于季戊四醇的聚叠氮化物的四面体DNA缀合物

  摘要：

  DNA纳米结构中的分支点通常是由Watson-Crick非共价相互作用维持的3或4位连接。但是，共价结合的DNA星可以改善DNA纳米级结构的多样性，强度和完整性。我们在这里报告3和4季戊四醇基叠氮化物的方便合成及其通过化学计量控制铜（I）催化的叠氮化物炔烃用于组装包含相同或不同寡核苷酸（ODNs）和/或荧光染料的支链共轭物的用途环加成（CuAAC）功能化。

  DOI：

  10.1016/j.tet.2016.03.051

文献信息

• Novel synthetic LPDs consisting of different cholesterol derivatives for gene transfer into hepatocytes
  作者：Jiao Lu、Di Zhu、Zhi-Rong Zhang、Li Hai、Yong Wu、Xun Sun

  DOI：10.3109/10611860903548370

  日期：2010.8

  In the present study, LPDs composing of a series of novel synthetic cholesterylated derivatives bearing a cluster of galactose residues and different spacer lengths were prepared for performing target gene delivery to hepatocytes and their physiochemical properties as well as gene transfer efficiency were investigated. In agreement with the "clustering effect" known to occur with more complex oligomeric structures, the addition of galactose residues under optimized spatial arrangement condition invariably increased the transfect efficiency into hepatoma cells, which can be owed to the sufficient binding of galactose ligands to the ASGPR on hepatocytes. However, the gene transfer ability to hepatocytes was not always improved with extended spacer arms, suggesting a spatial binding sites arrangement of the receptor. Moreover, our research has established galactosylated LPDs, specifically, LPDIIb, LPDIIIc, and LPDIVe as potential vectors to deliver special genes into hepatocytes with low toxicity, combining the condensing effect of protamine and the targeting capability of cholesterylated thiogalactosides.
• Tetrahedral DNA conjugates from pentaerythritol-based polyazides
  作者：Anna I. Ponomarenko、Vladimir A. Brylev、Ksenia A. Sapozhnikova、Alexey V. Ustinov、Igor A. Prokhorenko、Timofei S. Zatsepin、Vladimir A. Korshun

  DOI：10.1016/j.tet.2016.03.051

  日期：2016.5

  strength and integrity of DNA nanoscale constructions. We report here the convenient synthesis of 3- and 4-fold pentaerythritol-based azides and their use for the assembly of branched conjugates containing the same or different oligonucleotides (ODNs) and/or fluorescent dyes by stoichiometry controlled copper (I) catalyzed azide alkyne cycloaddition (CuAAC) functionalization.

  DNA纳米结构中的分支点通常是由Watson-Crick非共价相互作用维持的3或4位连接。但是，共价结合的DNA星可以改善DNA纳米级结构的多样性，强度和完整性。我们在这里报告3和4季戊四醇基叠氮化物的方便合成及其通过化学计量控制铜（I）催化的叠氮化物炔烃用于组装包含相同或不同寡核苷酸（ODNs）和/或荧光染料的支链共轭物的用途环加成（CuAAC）功能化。
• Improved Synthesis of an Ethereal Tetraamine Core for Dendrimer Construction
  作者：George R. Newkome、Amaresh Mishra、Charles N. Moorefield

  DOI：10.1021/jo025625p

  日期：2002.5.1

  A new route to a pentaerythritol-based tetraamine is delineated and subsequently contrasted to a previous report. Access to the pure tetraamine is facilitated by the smooth reduction of its tetraazide precusor. Characterization includes the preparation of a 4:1 Zn-tetraphenylporphyrin/tetraamine complex.